1-phenyl-2,5,8,11-tetraoxatridecan-13-oic acid tert-butyl ester

Base Information

• Chemical Name: 1-phenyl-2,5,8,11-tetraoxatridecan-13-oic acid tert-butyl ester
• CAS No.: 1443467-88-6
• Molecular Formula: C₁₉H₃₀O₆
• Molecular Weight: 354.444

Synonyms:1-phenyl-2,5,8,11-tetraoxatridecan-13-oic acid tert-butyl ester

Chemical Property of 1-phenyl-2,5,8,11-tetraoxatridecan-13-oic acid tert-butyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Benzyl-PEG4-CH2CO2tBu ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Benzyl-PEG4-CH2CO2tBu is a PEG linker with a benzyl and t-butyl protecting group. Both protecting groups are acid labile. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Technology Process of 1-phenyl-2,5,8,11-tetraoxatridecan-13-oic acid tert-butyl ester

There total 4 articles about 1-phenyl-2,5,8,11-tetraoxatridecan-13-oic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

bromoacetic acid tert-butyl ester (5292-43-3) + triethylene glycol monobenzyl ether (55489-58-2,1201808-31-2) → 1-phenyl-2,5,8,11-tetraoxatridecan-13-oic acid tert-butyl ester (1443467-88-6)

Guidance literature:

triethylene glycol monobenzyl ether; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1.25h;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at 80 ℃; for 10h;

DOI:10.1021/ja402423r

Reference yield:

2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → 1-phenyl-2,5,8,11-tetraoxatridecan-13-oic acid tert-butyl ester (1443467-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 0.5 h / 20 °C

1.2: 24 h / 100 °C

2.1: sodium hydride / tetrahydrofuran / 1.25 h / 0 - 20 °C

2.2: 10 h / 80 °C

With sodium hydride; sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1021/ja402423r

Reference yield:

benzyl chloride (100-44-7) → 1-phenyl-2,5,8,11-tetraoxatridecan-13-oic acid tert-butyl ester (1443467-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 0.5 h / 20 °C

1.2: 24 h / 100 °C

2.1: sodium hydride / tetrahydrofuran / 1.25 h / 0 - 20 °C

2.2: 10 h / 80 °C

With sodium hydride; sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1021/ja402423r

upstream raw materials:

bromoacetic acid tert-butyl ester

triethylene glycol monobenzyl ether

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

benzyl chloride

Downstream raw materials:

1-phenyl-2,5,8,11-tetraoxatridecan-13-oic acid

N-(6-(5-(1,2-dithiolan-3-yl)pentanamido)hexyl)-1-phenyl-2,5,8,11-tetraoxatridecan-13-amide

(2S,4R)-1-((S)-2-(tert-butyl)-20-((7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)-15-methyl-4-oxo-6,9,12-trioxa-3,15-diazaicosan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

tert-butyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate

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