6-[(E)-1-(4-Fluoro-phenyl)-4-trimethylsilanyl-but-1-en-3-ynyl]-1-(propane-2-sulfonyl)-1H-benzoimidazol-2-ylamine

Base Information

Chemical Name:6-[(E)-1-(4-Fluoro-phenyl)-4-trimethylsilanyl-but-1-en-3-ynyl]-1-(propane-2-sulfonyl)-1H-benzoimidazol-2-ylamine
CAS No.:186093-19-6
Molecular Formula:C₂₃H₂₆FN₃O₂SSi
Molecular Weight:455.628
Hs Code.:

Synonyms:6-[(E)-1-(4-Fluoro-phenyl)-4-trimethylsilanyl-but-1-en-3-ynyl]-1-(propane-2-sulfonyl)-1H-benzoimidazol-2-ylamine

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Chemical Property of 6-[(E)-1-(4-Fluoro-phenyl)-4-trimethylsilanyl-but-1-en-3-ynyl]-1-(propane-2-sulfonyl)-1H-benzoimidazol-2-ylamine

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Technology Process of 6-[(E)-1-(4-Fluoro-phenyl)-4-trimethylsilanyl-but-1-en-3-ynyl]-1-(propane-2-sulfonyl)-1H-benzoimidazol-2-ylamine

There total 7 articles about 6-[(E)-1-(4-Fluoro-phenyl)-4-trimethylsilanyl-but-1-en-3-ynyl]-1-(propane-2-sulfonyl)-1H-benzoimidazol-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 459-22-3
4-fluorophenylacetonitrile

: 186093-19-6
6-[(E)-1-(4-Fluoro-phenyl)-4-trimethylsilanyl-but-1-en-3-ynyl]-1-(propane-2-sulfonyl)-1H-benzoimidazol-2-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1: t-BuOK / dimethylformamide / 4 h / Ambient temperature

2: 30percent aq. H₂O₂ / dimethylformamide / 0 - 20 °C

3: H₂ / Raney nickel / tetrahydrofuran / 12 h / 3102.9 Torr

4: pyridine / CH₂Cl₂ / 5 h / Ambient temperature

5: 2N aq. NaOH / propan-2-ol; acetonitrile / Ambient temperature

6: 1.) LiHMDS / 1.) THF, -78 deg C, 30 min, 2.) THF, a) -78 deg C, 15 min, b) RT, overnight

With pyridine; sodium hydroxide; potassium tert-butylate; hydrogen; dihydrogen peroxide; lithium hexamethyldisilazane; nickel; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm970423k

Reference yield:

: 1635-61-6
5-chloro-2-nitroaniline

: 186093-19-6
6-[(E)-1-(4-Fluoro-phenyl)-4-trimethylsilanyl-but-1-en-3-ynyl]-1-(propane-2-sulfonyl)-1H-benzoimidazol-2-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1: t-BuOK / dimethylformamide / 4 h / Ambient temperature

2: 30percent aq. H₂O₂ / dimethylformamide / 0 - 20 °C

3: H₂ / Raney nickel / tetrahydrofuran / 12 h / 3102.9 Torr

4: pyridine / CH₂Cl₂ / 5 h / Ambient temperature

5: 2N aq. NaOH / propan-2-ol; acetonitrile / Ambient temperature

6: 1.) LiHMDS / 1.) THF, -78 deg C, 30 min, 2.) THF, a) -78 deg C, 15 min, b) RT, overnight

With pyridine; sodium hydroxide; potassium tert-butylate; hydrogen; dihydrogen peroxide; lithium hexamethyldisilazane; nickel; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm970423k

Reference yield:

: 180601-52-9
3-Amino-4-nitro-4'-fluorobenzophenone

: 186093-19-6
6-[(E)-1-(4-Fluoro-phenyl)-4-trimethylsilanyl-but-1-en-3-ynyl]-1-(propane-2-sulfonyl)-1H-benzoimidazol-2-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Raney nickel / tetrahydrofuran / 12 h / 3102.9 Torr

2: pyridine / CH₂Cl₂ / 5 h / Ambient temperature

3: 2N aq. NaOH / propan-2-ol; acetonitrile / Ambient temperature

4: 1.) LiHMDS / 1.) THF, -78 deg C, 30 min, 2.) THF, a) -78 deg C, 15 min, b) RT, overnight

With pyridine; sodium hydroxide; hydrogen; lithium hexamethyldisilazane; nickel; In tetrahydrofuran; dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm970423k