2-PHENYL-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

Base Information

• Chemical Name: 2-PHENYL-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
• CAS No.: 455955-08-5
• Molecular Formula: C₁₆H₂₁NO₄
• Molecular Weight: 291.347
• Mol file: 455955-08-5.mol

Synonyms:(?à)-1-(tert-Butoxycarbonyl)-2-phenylpyrrolidine-3-carboxylicacid

Chemical Property of 2-PHENYL-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

Chemical Property:

• PSA: 66.84000
• LogP: 3.00720

Purity/Quality:

97% ^*data from raw suppliers

2-Phenyl-pyrrolidine-1,3-dicarboxylicacid1-tert-butylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PHENYL-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

There total 9 articles about 2-PHENYL-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2R,3R)-2-phenylpyrrolidine-3-carboxylic acid (1241684-18-3,1241681-66-2) + di-tert-butyl dicarbonate (24424-99-5) → (2R,3R)-2-phenyl-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester (455955-08-5,870721-53-2)

Guidance literature:

With triethylamine; In 1,4-dioxane; water;

Reference yield: 86.0%

(2R,3S)-3-Hydroxymethyl-2-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester → (2R,3S)-1-(tert-butoxycarbonyl)-2-phenylpyrrolidine-3-carboxylic acid (1238895-40-3,455955-08-5,870721-53-2)

Guidance literature:

(2R,3S)-3-Hydroxymethyl-2-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester; With ruthenium (III) chloride hydrate; water; In tetrachloromethane; acetonitrile; for 0.166667h; Inert atmosphere;

With sodium periodate; In tetrachloromethane; acetonitrile; for 2h; Inert atmosphere;

DOI:10.1002/ejoc.201000255

Reference yield: 71.0%

1-(tert-butyl) 3-methyl 2-phenylpyrrolidine-1,3-dicarboxylate → 1-(tert-butoxycarbonyl)-2-phenylpyrrolidine-3-carboxylic acid (455955-08-5,870721-53-2)

Guidance literature:

With sodium hydroxide; In methanol; at 80 ℃; for 16h;

upstream raw materials:

(2R,3R)-2-phenylpyrrolidine-3-carboxylic acid

di-tert-butyl dicarbonate

benzaldehyde