4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl-benzothioate

Base Information

Chemical Name:4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl-benzothioate
CAS No.:1012058-05-7
Molecular Formula:C₂₂H₁₅ClFN₃O₂S
Molecular Weight:439.897
Hs Code.:

Synonyms:4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl-benzothioate

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Chemical Property of 4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl-benzothioate

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Technology Process of 4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl-benzothioate

There total 1 articles about 4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl-benzothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 98-91-9
thiobenzoic acid

: 1012920-25-0
C₁₅H₁₀ClFIN₃O

: 1012058-05-7
4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl-benzothioate

Guidance literature:: With copper(l) iodide; 1,10-Phenanthroline; N-ethyl-N,N-diisopropylamine; In toluene; at 110 ℃; for 24h;

Reference yield: 26.0%

: 1012058-05-7
4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl-benzothioate

: 29823-18-5
ethyl 7-bromoheptanoate

: 1012058-08-0
ethyl 7-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylthio)heptanoate

Guidance literature:: 4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl-benzothioate; With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 6h;

ethyl 7-bromoheptanoate; In N,N-dimethyl-formamide; for 3h;
DOI:10.1021/jm901453q

Reference yield: 16.0%

: 1012058-05-7
4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl-benzothioate

: 2969-81-5
Ethyl 4-bromobutyrate

: 1012058-06-8
C₂₁H₂₁ClFN₃O₃S

Guidance literature:: 4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl-benzothioate; With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 6h;

Ethyl 4-bromobutyrate; In N,N-dimethyl-formamide; for 3h;