2-(4-isopropyl-3,5-dimethoxy-benzoyl)-5-methyl-hex-5-enoic acid methyl ester

Base Information

Chemical Name:2-(4-isopropyl-3,5-dimethoxy-benzoyl)-5-methyl-hex-5-enoic acid methyl ester
CAS No.:866821-38-7
Molecular Formula:C₂₀H₂₈O₅
Molecular Weight:348.439
Hs Code.:

Synonyms:2-(4-isopropyl-3,5-dimethoxy-benzoyl)-5-methyl-hex-5-enoic acid methyl ester

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Chemical Property of 2-(4-isopropyl-3,5-dimethoxy-benzoyl)-5-methyl-hex-5-enoic acid methyl ester

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Technology Process of 2-(4-isopropyl-3,5-dimethoxy-benzoyl)-5-methyl-hex-5-enoic acid methyl ester

There total 6 articles about 2-(4-isopropyl-3,5-dimethoxy-benzoyl)-5-methyl-hex-5-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 866821-37-6
methyl 3-(4-isopropyl-3,5-dimethoxyphenyl)-3-oxopropanoate

: 53750-52-0
4-iodo-2-methyl-but-1-ene

: 866821-38-7
2-(4-isopropyl-3,5-dimethoxy-benzoyl)-5-methyl-hex-5-enoic acid methyl ester

Guidance literature:: methyl 3-(4-isopropyl-3,5-dimethoxyphenyl)-3-oxopropanoate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

4-iodo-2-methyl-but-1-ene; In N,N-dimethyl-formamide; at 70 ℃; for 13h;
DOI:10.1021/ja054447p

Reference yield:

: 866821-31-0
methyl 3,5-dimethoxy-4-(prop-1-en-2-yl)benzoate

: 866821-38-7
2-(4-isopropyl-3,5-dimethoxy-benzoyl)-5-methyl-hex-5-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₂ / Pd/C / ethyl acetate / 4 h / 20 °C

2.1: 1.81 g / aq. NaOH / 0.5 h / Heating

3.1: 96 percent / diethyl ether / 0 - 20 °C

4.1: NaH / tetrahydrofuran / Heating

4.2: 93 percent / tetrahydrofuran / 1.5 h

5.1: NaH / dimethylformamide / 3 h / 20 °C

5.2: 79 percent / dimethylformamide / 13 h / 70 °C

With sodium hydroxide; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja054447p

Reference yield:

: 26050-64-6
methyl 4-bromo-3,5-dimethoxybenzoate

: 866821-38-7
2-(4-isopropyl-3,5-dimethoxy-benzoyl)-5-methyl-hex-5-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 88 percent / CsF; Pd(tBu₃P)2 / tetrahydrofuran / 12 h / Heating

2.1: H₂ / Pd/C / ethyl acetate / 4 h / 20 °C

3.1: 1.81 g / aq. NaOH / 0.5 h / Heating

4.1: 96 percent / diethyl ether / 0 - 20 °C

5.1: NaH / tetrahydrofuran / Heating

5.2: 93 percent / tetrahydrofuran / 1.5 h

6.1: NaH / dimethylformamide / 3 h / 20 °C

6.2: 79 percent / dimethylformamide / 13 h / 70 °C

With sodium hydroxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; hydrogen; sodium hydride; cesium fluoride; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethyl acetate; N,N-dimethyl-formamide; 1.1: Stille cross-coupling;
DOI:10.1021/ja054447p