4-[2-(5,6-difluoro-1H-benzoimidazol-2-yl)-benzyloxy]-3-fluoro-benzonitrile

Base Information

Chemical Name:4-[2-(5,6-difluoro-1H-benzoimidazol-2-yl)-benzyloxy]-3-fluoro-benzonitrile
CAS No.:1281981-35-8
Molecular Formula:C₂₁H₁₂F₃N₃O
Molecular Weight:379.341
Hs Code.:

Synonyms:4-[2-(5,6-difluoro-1H-benzoimidazol-2-yl)-benzyloxy]-3-fluoro-benzonitrile

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Chemical Property of 4-[2-(5,6-difluoro-1H-benzoimidazol-2-yl)-benzyloxy]-3-fluoro-benzonitrile

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Technology Process of 4-[2-(5,6-difluoro-1H-benzoimidazol-2-yl)-benzyloxy]-3-fluoro-benzonitrile

There total 5 articles about 4-[2-(5,6-difluoro-1H-benzoimidazol-2-yl)-benzyloxy]-3-fluoro-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1281981-36-9
2-(4-cyano-2-fluoro-phenoxymethyl)-benzoyl chloride

: 76179-40-3
2-amino-4,5-difluoroaniline

: 1281981-35-8
4-[2-(5,6-difluoro-1H-benzoimidazol-2-yl)-benzyloxy]-3-fluoro-benzonitrile

Guidance literature:: 2-(4-cyano-2-fluoro-phenoxymethyl)-benzoyl chloride; 2-amino-4,5-difluoroaniline; With triethylamine; In dichloromethane; at 0 ℃; for 3.16667h;

With sodium acetate; acetic acid; In dichloromethane; for 13h; Reflux;

Reference yield:

: 405-04-9
3-fluoro-4-hydroxybenzonitrile

: 1281981-35-8
4-[2-(5,6-difluoro-1H-benzoimidazol-2-yl)-benzyloxy]-3-fluoro-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / acetone / 12 h / Reflux

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 12 h / 25 °C

2.2: pH 5

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 12 h / 25 °C

4.1: triethylamine / dichloromethane / 3.17 h / 0 °C

4.2: 13 h / Reflux

With oxalyl dichloride; lithium hydroxide monohydrate; water; caesium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; acetone;

Reference yield:

: 2417-73-4
methyl 2-bromomethylbenzoate

: 1281981-35-8
4-[2-(5,6-difluoro-1H-benzoimidazol-2-yl)-benzyloxy]-3-fluoro-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / acetone / 12 h / Reflux

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 12 h / 25 °C

2.2: pH 5

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 12 h / 25 °C

4.1: triethylamine / dichloromethane / 3.17 h / 0 °C

4.2: 13 h / Reflux

With oxalyl dichloride; lithium hydroxide monohydrate; water; caesium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; acetone;