(-)-(R)-(phenyl)(phenylmethoxycarbonylamino)acetic acid 3,3-dimethyl-2-oxo-butyl ester

Base Information

Chemical Name:(-)-(R)-(phenyl)(phenylmethoxycarbonylamino)acetic acid 3,3-dimethyl-2-oxo-butyl ester
CAS No.:261963-27-3
Molecular Formula:C₂₂H₂₅NO₅
Molecular Weight:383.444
Hs Code.:

Synonyms:(-)-(R)-(phenyl)(phenylmethoxycarbonylamino)acetic acid 3,3-dimethyl-2-oxo-butyl ester

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Chemical Property of (-)-(R)-(phenyl)(phenylmethoxycarbonylamino)acetic acid 3,3-dimethyl-2-oxo-butyl ester

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Technology Process of (-)-(R)-(phenyl)(phenylmethoxycarbonylamino)acetic acid 3,3-dimethyl-2-oxo-butyl ester

There total 1 articles about (-)-(R)-(phenyl)(phenylmethoxycarbonylamino)acetic acid 3,3-dimethyl-2-oxo-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 5469-26-1
1-Bromopinacolon

: (R)-(phenyl)(phenylmethoxycarbonylamino)acetic acid potassium salt

: 261963-27-3
(-)-(R)-(phenyl)(phenylmethoxycarbonylamino)acetic acid 3,3-dimethyl-2-oxo-butyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1016/S0040-4020(99)00935-7

Reference yield:

: 261963-27-3
(-)-(R)-(phenyl)(phenylmethoxycarbonylamino)acetic acid 3,3-dimethyl-2-oxo-butyl ester

: 112245-13-3
(S)-tert-leucinol

Guidance literature:: Multi-step reaction with 4 steps

1: hydrobromic acid; acetic acid

2: potassium carbonate

3: hydrogen / platinum oxide hydrate / methanol / 20 °C / 760 Torr

4: 82 percent / hydrogen / Pd/C / methanol / 72 h / 114000 Torr

With hydrogen bromide; hydrogen; potassium carbonate; acetic acid; platinum(IV) oxide; palladium on activated charcoal; In methanol; 1: Hydrolysis / 2: Cyclization / 3: Catalytic hydrogenation / 4: Hydrogenolysis;
DOI:10.1016/S0040-4020(99)00935-7

Reference yield:

: 261963-27-3
(-)-(R)-(phenyl)(phenylmethoxycarbonylamino)acetic acid 3,3-dimethyl-2-oxo-butyl ester

: (3R,5R)-5-(1,1-dimethylethyl)-3-phenylmorpholin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrobromic acid; acetic acid

2: potassium carbonate

3: hydrogen / platinum oxide hydrate / methanol / 20 °C / 760 Torr

With hydrogen bromide; hydrogen; potassium carbonate; acetic acid; platinum(IV) oxide; In methanol; 1: Hydrolysis / 2: Cyclization / 3: Catalytic hydrogenation;
DOI:10.1016/S0040-4020(99)00935-7