1-<3-deoxy-3-α-ethynyl-5-O-(triphenylmethyl)-β-D-arabinofuranosyl>pyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 1-<3-deoxy-3-α-ethynyl-5-O-(triphenylmethyl)-β-D-arabinofuranosyl>pyrimidine-2,4(1H,3H)-dione
• CAS No.: 96253-11-1
• Molecular Formula: C₃₀H₂₆N₂O₅
• Molecular Weight: 494.547
• Mol file: 96253-11-1.mol

Synonyms:1-<3-deoxy-3-α-ethynyl-5-O-(triphenylmethyl)-β-D-arabinofuranosyl>pyrimidine-2,4(1H,3H)-dione

Chemical Property of 1-<3-deoxy-3-α-ethynyl-5-O-(triphenylmethyl)-β-D-arabinofuranosyl>pyrimidine-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<3-deoxy-3-α-ethynyl-5-O-(triphenylmethyl)-β-D-arabinofuranosyl>pyrimidine-2,4(1H,3H)-dione

There total 3 articles about 1-<3-deoxy-3-α-ethynyl-5-O-(triphenylmethyl)-β-D-arabinofuranosyl>pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-[2,3-epoxy-5-O-(triphenylmethyl)-β-D-lyxofuranosyl]pyrimidine-2,4(1H,3H)-dione (96253-10-0) → 1-<3-deoxy-3-α-ethynyl-5-O-(triphenylmethyl)-β-D-arabinofuranosyl>pyrimidine-2,4(1H,3H)-dione (96253-11-1)

Guidance literature:

In dimethyl sulfoxide; for 3h; Ambient temperature;

DOI:10.1002/hlca.19950780721

Reference yield: 68.0%

1-[2,3-epoxy-5-O-(triphenylmethyl)-β-D-lyxofuranosyl]pyrimidine-2,4(1H,3H)-dione (96253-10-0) + lithium acetylide (70277-75-7) → 1-<3-deoxy-3-α-ethynyl-5-O-(triphenylmethyl)-β-D-arabinofuranosyl>pyrimidine-2,4(1H,3H)-dione (96253-11-1)

Guidance literature:

With ethylenediamine; In dimethyl sulfoxide;

DOI:10.1016/S0040-4039(00)98477-6

Reference yield:

uridine (58-96-8) → 1-<3-deoxy-3-α-ethynyl-5-O-(triphenylmethyl)-β-D-arabinofuranosyl>pyrimidine-2,4(1H,3H)-dione (96253-11-1)

Guidance literature:

Multi-step reaction with 2 steps

2: 68 percent / ethylenediamine / dimethylsulfoxide

With ethylenediamine; In dimethyl sulfoxide;

DOI:10.1016/S0040-4039(00)98477-6

upstream raw materials:

1-[2,3-epoxy-5-O-(triphenylmethyl)-β-D-lyxofuranosyl]pyrimidine-2,4(1H,3H)-dione

lithium acetylide

uridine

Downstream raw materials:

1-<2,3-dideoxy-3-ethynyl-5-O-(triphenylmethyl)-β-D-ribofuranosyl>pyrimidine-2,4(1H,3H)-dione

1-<3-deoxy-3-α-ethynyl-2-O--5-O-(triphenylmethyl)-β-D-arabinofuranosyl>pyrimidine-2,4(1H,3H)-dione

1-<2-O-acetyl-3-deoxy-3-α-ethynyl-5-O-(triphenylmethyl)-β-D-arabinofuranosyl>pyrimidine-2,4(1H,3H)-dione