1-(azetidin-1-yl)-2-(2-fluoro-4-{2-[(1S,2R)-2-{1-[5-(methoxymethyl)pyridin-2-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)ethanone

Base Information

Chemical Name:1-(azetidin-1-yl)-2-(2-fluoro-4-{2-[(1S,2R)-2-{1-[5-(methoxymethyl)pyridin-2-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)ethanone
CAS No.:1437778-64-7
Molecular Formula:C₂₈H₃₆FN₃O₃
Molecular Weight:481.611
Hs Code.:

Synonyms:1-(azetidin-1-yl)-2-(2-fluoro-4-{2-[(1S,2R)-2-{1-[5-(methoxymethyl)pyridin-2-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)ethanone

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Chemical Property of 1-(azetidin-1-yl)-2-(2-fluoro-4-{2-[(1S,2R)-2-{1-[5-(methoxymethyl)pyridin-2-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)ethanone

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Technology Process of 1-(azetidin-1-yl)-2-(2-fluoro-4-{2-[(1S,2R)-2-{1-[5-(methoxymethyl)pyridin-2-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)ethanone

There total 18 articles about 1-(azetidin-1-yl)-2-(2-fluoro-4-{2-[(1S,2R)-2-{1-[5-(methoxymethyl)pyridin-2-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68886-07-7
(2-fluoro-4-hydroxylphenyl)acetic acid

: 1437778-64-7
1-(azetidin-1-yl)-2-(2-fluoro-4-{2-[(1S,2R)-2-{1-[5-(methoxymethyl)pyridin-2-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 3 h / 20 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 2 h / 20 °C

With di-isopropyl azodicarboxylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In dichloromethane; toluene;

Reference yield:

: 1402555-51-4
1-(azetidin-1-yl)-2-(2-fluoro-4-hydroxyphenyl)ethanone

: 1437779-16-2
2-[(1S,2R)-2-{1-[5-(methoxymethyl)pyridin-2-yl]piperidin-4-yl}cyclopropyl]ethanol

: 1437778-64-7
1-(azetidin-1-yl)-2-(2-fluoro-4-{2-[(1S,2R)-2-{1-[5-(methoxymethyl)pyridin-2-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)ethanone

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 20 ℃; for 2h;

Reference yield:

: cis-tert-butyl 4-[2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate

: 1437778-64-7
1-(azetidin-1-yl)-2-(2-fluoro-4-{2-[(1S,2R)-2-{1-[5-(methoxymethyl)pyridin-2-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)ethanone

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogenchloride / 2 h / 20 °C

2.1: triethylamine / ethyl acetate / 4 h / Reflux

3.1: dipotassium hydrogenphosphate; sodium carbonate / water; dimethyl sulfoxide; methanol / 7 h / 21 - 25 °C / pH 7 - 8 / Enzymatic reaction

3.2: 0.5 h / 40 °C / pH Ca_. 14

4.1: palladium on carbon; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr

5.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

6.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

7.1: methanol; sodium tetrahydroborate / 1 h / 20 °C

8.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

10.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 2 h / 20 °C

With 1H-imidazole; hydrogenchloride; methanol; sodium tetrahydroborate; dipotassium hydrogenphosphate; di-isopropyl azodicarboxylate; palladium on carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hexamethyldisilazane; sodium carbonate; caesium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;