N-p-tolylclavulanamide

Base Information

Chemical Name:N-p-tolylclavulanamide
CAS No.:62868-60-4
Molecular Formula:C₁₅H₁₆N₂O₄
Molecular Weight:288.303
Hs Code.:

Synonyms:N-p-tolylclavulanamide

Suppliers and Price of N-p-tolylclavulanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-p-tolylclavulanamide

Chemical Property:

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Technology Process of N-p-tolylclavulanamide

There total 5 articles about N-p-tolylclavulanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 540-23-8
p-toluidine hydrochloride

: 57943-81-4
potassium clavulanate

: 62868-60-4
N-p-tolylclavulanamide

Guidance literature:: With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; In 1,4-dioxane; water; at 0 ℃; for 1h;

Reference yield:

: 57943-82-5
methyl clavulanate

: 62868-60-4
N-p-tolylclavulanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / sodium hydroxide / H₂O / 1.17 h / 0 °C

2: 65 percent / 1-cyclohexyl-3-(2-morpholinoethyl)-N-methylcarbodi-imidinium toluene-p-sulphonate / H₂O; dioxane / 1 h / 0 °C

With sodium hydroxide; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; In 1,4-dioxane; water;

Reference yield:

: 57943-84-7
Benzyl Clavulanate

: 62868-60-4
N-p-tolylclavulanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / H₂, sodium hydrogen carbonate / palladium on carbon / aq. ethanol / 0.42 h / Ambient temperature

2: 65 percent / 1-cyclohexyl-3-(2-morpholinoethyl)-N-methylcarbodi-imidinium toluene-p-sulphonate / H₂O; dioxane / 1 h / 0 °C

With hydrogen; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; sodium hydrogencarbonate; palladium on activated charcoal; In 1,4-dioxane; ethanol; water;