2-ANILINOPYRIMIDINE-5-CARBOXYLIC ACID

Base Information

• Chemical Name: 2-ANILINOPYRIMIDINE-5-CARBOXYLIC ACID
• CAS No.: 450368-25-9
• Molecular Formula: C11H9 N3 O2
• Molecular Weight: 215.21
• Hs Code.: 2933599090
• Mol file: 450368-25-9.mol

Synonyms:2-(Phenylamino)pyrimidine-5-carboxylicacid

Chemical Property of 2-ANILINOPYRIMIDINE-5-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.686
• Boiling Point: 469.622ºC at 760 mmHg
• Flash Point: 237.819ºC
• PSA: 75.11000
• Density: 1.393g/cm3
• LogP: 1.99140

Purity/Quality:

98% ^*data from raw suppliers

2-Anilinopyrimidine-5-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Anilinopyrimidine-5-carboxylic Acid can be used for useful organic synthesis.

Technology Process of 2-ANILINOPYRIMIDINE-5-CARBOXYLIC ACID

There total 3 articles about 2-ANILINOPYRIMIDINE-5-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.4%

ethyl 2-(phenylamino)pyrimidine-5-carboxylate (864172-93-0) → C11H9N3O2 (450368-25-9)

Guidance literature:

With water monomer; lithium hydroxide monohydrate; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1111/cbdd.14055

Reference yield:

C12H11N3O2 (937796-09-3) → C11H9N3O2 (450368-25-9)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

DOI:10.1021/jm500007h

Reference yield:

(5-bromo-pyrimidin-2-yl)-phenyl-amine (886365-88-4) → C11H9N3O2 (450368-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 12 h / 100 °C

2: lithium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 °C

With water; palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm500007h

upstream raw materials:

(5-bromo-pyrimidin-2-yl)-phenyl-amine

C₁₂H₁₁N₃O₂

ethyl 2-(phenylamino)pyrimidine-5-carboxylate

Downstream raw materials:

N-(2-methyl-5-((4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)phenyl)-2-(phenylamino)pyrimidine-5-carboxamide