(3β,5Z,7E)-3-t-butyldimethylsilyloxy-24-oxa-9,10-secocholesta-5,7,10(19)-triene

Base Information

Chemical Name:(3β,5Z,7E)-3-t-butyldimethylsilyloxy-24-oxa-9,10-secocholesta-5,7,10(19)-triene
CAS No.:147833-12-3
Molecular Formula:C₃₂H₅₆O₂Si
Molecular Weight:500.881
Hs Code.:

Synonyms:(3β,5Z,7E)-3-t-butyldimethylsilyloxy-24-oxa-9,10-secocholesta-5,7,10(19)-triene

Suppliers and Price of (3β,5Z,7E)-3-t-butyldimethylsilyloxy-24-oxa-9,10-secocholesta-5,7,10(19)-triene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3β,5Z,7E)-3-t-butyldimethylsilyloxy-24-oxa-9,10-secocholesta-5,7,10(19)-triene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3β,5Z,7E)-3-t-butyldimethylsilyloxy-24-oxa-9,10-secocholesta-5,7,10(19)-triene

There total 9 articles about (3β,5Z,7E)-3-t-butyldimethylsilyloxy-24-oxa-9,10-secocholesta-5,7,10(19)-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55812-82-3,63730-57-4,63730-58-5,102281-42-5
(1R,3aR,4S,7aR)-7a-methyl-1-<(2E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl>-octahydro-1H-inden-4-ol

: 147833-12-3
(3β,5Z,7E)-3-t-butyldimethylsilyloxy-24-oxa-9,10-secocholesta-5,7,10(19)-triene

Guidance literature:: Multi-step reaction with 9 steps

1: 93 percent / i-Pr₂NH, 4-dimethylaminopyridine / CH₂Cl₂ / 16 h / Ambient temperature

2: 1) O₃, pyridine, 2) NaBH₄ / 1) MeOH, CH₂Cl₂, -78 deg C, 30 min, 2) rt, 4 h

3: 90 percent / pyridine / 72 h / 4 °C

4: 95 percent / dimethylsulfoxide / 4 h / 90 °C

6: 1) NaH / 1) DMF, hexane, 1 h, rt, 2) 24 h

7: 97 percent / AG 50W-X₄ / methanol / 96 h

8: 98 percent / pyridinium dichromate, pyridinium tosylate / CH₂Cl₂ / 12 h

9: 1) n-BuLi / 1) THF, hexane, -78 deg C, 30 min, 2) THF, a) -78 deg C, 1 h, b) rt, 3 h

With pyridine; dmap; sodium tetrahydroborate; dipyridinium dichromate; n-butyllithium; AG 50W-X₄; pyridinium p-toluenesulfonate; sodium hydride; ozone; diisopropylamine; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(01)86275-X

Reference yield:

: 147833-11-2
(8β)-de-A,B-24-oxacholestan-8-ol

: 147833-12-3
(3β,5Z,7E)-3-t-butyldimethylsilyloxy-24-oxa-9,10-secocholesta-5,7,10(19)-triene

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / pyridinium dichromate, pyridinium tosylate / CH₂Cl₂ / 12 h

2: 1) n-BuLi / 1) THF, hexane, -78 deg C, 30 min, 2) THF, a) -78 deg C, 1 h, b) rt, 3 h

With dipyridinium dichromate; n-butyllithium; pyridinium p-toluenesulfonate; In dichloromethane;
DOI:10.1016/S0040-4020(01)86275-X

Reference yield:

: 147833-08-7
(8β)-de-A,B-8-methoxymethyloxy-23,24-dinorcholan-22-ol

: 147833-12-3
(3β,5Z,7E)-3-t-butyldimethylsilyloxy-24-oxa-9,10-secocholesta-5,7,10(19)-triene

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / pyridine / 72 h / 4 °C

2: 95 percent / dimethylsulfoxide / 4 h / 90 °C

4: 1) NaH / 1) DMF, hexane, 1 h, rt, 2) 24 h

5: 97 percent / AG 50W-X₄ / methanol / 96 h

6: 98 percent / pyridinium dichromate, pyridinium tosylate / CH₂Cl₂ / 12 h

7: 1) n-BuLi / 1) THF, hexane, -78 deg C, 30 min, 2) THF, a) -78 deg C, 1 h, b) rt, 3 h

With pyridine; dipyridinium dichromate; n-butyllithium; AG 50W-X₄; pyridinium p-toluenesulfonate; sodium hydride; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(01)86275-X