(R,E)-8-acetoxy-4-aza-3-isopropyl-4-(p-toluenesulfonyl)-7-[(triethyl)silyl]oct-6-enenitrile

Base Information

Chemical Name:(R,E)-8-acetoxy-4-aza-3-isopropyl-4-(p-toluenesulfonyl)-7-[(triethyl)silyl]oct-6-enenitrile
CAS No.:1254356-70-1
Molecular Formula:C₂₅H₄₀N₂O₄SSi
Molecular Weight:492.755
Hs Code.:

Synonyms:(R,E)-8-acetoxy-4-aza-3-isopropyl-4-(p-toluenesulfonyl)-7-[(triethyl)silyl]oct-6-enenitrile

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Chemical Property of (R,E)-8-acetoxy-4-aza-3-isopropyl-4-(p-toluenesulfonyl)-7-[(triethyl)silyl]oct-6-enenitrile

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Technology Process of (R,E)-8-acetoxy-4-aza-3-isopropyl-4-(p-toluenesulfonyl)-7-[(triethyl)silyl]oct-6-enenitrile

There total 6 articles about (R,E)-8-acetoxy-4-aza-3-isopropyl-4-(p-toluenesulfonyl)-7-[(triethyl)silyl]oct-6-enenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 875438-79-2
(3R)-3-(p-toluenesulfonyl)amino-4-methylpentanenitrile

: 607389-95-7
(E)-1-acetoxy-4-chloro-2-[(triethyl)silyl]but-2-ene

: 1254356-70-1
(R,E)-8-acetoxy-4-aza-3-isopropyl-4-(p-toluenesulfonyl)-7-[(triethyl)silyl]oct-6-enenitrile

Guidance literature:: (3R)-3-(p-toluenesulfonyl)amino-4-methylpentanenitrile; With caesium carbonate; In acetonitrile; at 20 ℃; for 0.5h;

(E)-1-acetoxy-4-chloro-2-[(triethyl)silyl]but-2-ene; With tetra-(n-butyl)ammonium iodide; In acetonitrile; at 0 - 20 ℃; for 12h;
DOI:10.1021/jo101631y

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 1254356-70-1
(R,E)-8-acetoxy-4-aza-3-isopropyl-4-(p-toluenesulfonyl)-7-[(triethyl)silyl]oct-6-enenitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane

2.1: N,N-dimethyl-formamide

3.1: caesium carbonate / acetonitrile / 0.5 h / 20 °C

3.2: 12 h / 0 - 20 °C

With pyridine; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo101631y

Reference yield:

: 83466-88-0
4-acetoxy-2-butyn-1-ol

: 1254356-70-1
(R,E)-8-acetoxy-4-aza-3-isopropyl-4-(p-toluenesulfonyl)-7-[(triethyl)silyl]oct-6-enenitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂PtCl₆ / tetrahydrofuran / 20 °C

2.1: tetrachloromethane; triphenylphosphine / acetonitrile / 0.33 h / Reflux

3.1: caesium carbonate / acetonitrile / 0.5 h / 20 °C

3.2: 12 h / 0 - 20 °C

With tetrachloromethane; H₂PtCl₆; caesium carbonate; triphenylphosphine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo101631y