(-)-(1'S,2'S,2R)-4-(2'-Hydroxy-2',6',6'-trimethylcyclohexyl)-2-methylbutanoic acid

Base Information

Chemical Name:(-)-(1'S,2'S,2R)-4-(2'-Hydroxy-2',6',6'-trimethylcyclohexyl)-2-methylbutanoic acid
CAS No.:224048-12-8
Molecular Formula:C₁₄H₂₆O₃
Molecular Weight:242.359
Hs Code.:

Synonyms:(-)-(1'S,2'S,2R)-4-(2'-Hydroxy-2',6',6'-trimethylcyclohexyl)-2-methylbutanoic acid

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Chemical Property of (-)-(1'S,2'S,2R)-4-(2'-Hydroxy-2',6',6'-trimethylcyclohexyl)-2-methylbutanoic acid

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Technology Process of (-)-(1'S,2'S,2R)-4-(2'-Hydroxy-2',6',6'-trimethylcyclohexyl)-2-methylbutanoic acid

There total 13 articles about (-)-(1'S,2'S,2R)-4-(2'-Hydroxy-2',6',6'-trimethylcyclohexyl)-2-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: (-)-(1S,4R,7S)-1,4,8,8-Tetramethyl-2-oxabicyclo<5.4.0>undecan-3-one

: 224048-12-8
(-)-(1'S,2'S,2R)-4-(2'-Hydroxy-2',6',6'-trimethylcyclohexyl)-2-methylbutanoic acid

Guidance literature:: With sodium hydroxide; water; In ethanol; for 7h; Ambient temperature;

Reference yield:

: (3R,5aS,9aS)-3,6,6,9a-Tetramethyl-octahydro-benzo[b]oxepin-2-one

: 224048-12-8
(-)-(1'S,2'S,2R)-4-(2'-Hydroxy-2',6',6'-trimethylcyclohexyl)-2-methylbutanoic acid

Guidance literature:: With sodium hydroxide; In ethanol;
DOI:10.1021/jm100531u

Reference yield:

: 26742-33-6
(4aS)-1,4aβ-dimethyl-4,4a,7,8-tetrahydronaphthalene-2,5(3H,6H)-dione-5-ethyeneacetal

: 224048-12-8
(-)-(1'S,2'S,2R)-4-(2'-Hydroxy-2',6',6'-trimethylcyclohexyl)-2-methylbutanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: ammonia; lithium

2: sodium tetrahydroborate / ethanol

3: n-butyllithium / tetrahydrofuran

4: toluene-4-sulfonic acid / acetone

5: lithium diisopropyl amide / tetrahydrofuran

6: sodium hydride / methanol

7: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / neat (no solvent)

8: sodium hydroxide / ethanol

With sodium tetrahydroborate; n-butyllithium; ammonia; lithium; sodium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; acetone; 1: Birch reduction / 3: Barton-McCombie deoxygenation / 3: Barton-McCombie deoxygenation / 7: Baeyer-Villiger oxidation;
DOI:10.1021/jm100531u