1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-5-methyl-hex-4-en-1-ol

Base Information

• Chemical Name: 1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-5-methyl-hex-4-en-1-ol
• CAS No.: 1360148-39-5
• Molecular Formula: C₂₃H₂₇NO₂
• Molecular Weight: 349.473
• Mol file: 1360148-39-5.mol

Synonyms:1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-5-methyl-hex-4-en-1-ol

Chemical Property of 1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-5-methyl-hex-4-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-5-methyl-hex-4-en-1-ol

There total 6 articles about 1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-5-methyl-hex-4-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-methoxy-benzyl)-5-methyl-1H-indole-2-carboxylic acid ethyl ester (1360148-54-4) → 1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-5-methyl-hex-4-en-1-ol (1360148-39-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

2.1: manganese(IV) oxide / tetrachloromethane / 10 h / 20 °C

3.1: magnesium / diethyl ether / 2 h / 20 °C

3.2: 0 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; magnesium; In tetrahydrofuran; tetrachloromethane; diethyl ether; 3.2: Grignard reaction;

DOI:10.5012/bkcs.2011.32.12.4309

Reference yield:

[1-(4-methoxy-benzyl)-5-methyl-1H-indol-2-yl]-methanol (1360148-58-8) → 1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-5-methyl-hex-4-en-1-ol (1360148-39-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: manganese(IV) oxide / tetrachloromethane / 10 h / 20 °C

2.1: magnesium / diethyl ether / 2 h / 20 °C

2.2: 0 °C

With manganese(IV) oxide; magnesium; In tetrachloromethane; diethyl ether; 2.2: Grignard reaction;

DOI:10.5012/bkcs.2011.32.12.4309

Reference yield:

5-methyl-1H-indole-2-carboxylic acid ethyl ester (16382-15-3) → 1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-5-methyl-hex-4-en-1-ol (1360148-39-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 6 h

1.2: 24 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

3.1: manganese(IV) oxide / tetrachloromethane / 10 h / 20 °C

4.1: magnesium / diethyl ether / 2 h / 20 °C

4.2: 0 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium hydride; magnesium; In tetrahydrofuran; tetrachloromethane; diethyl ether; dimethyl sulfoxide; mineral oil; 4.2: Grignard reaction;

DOI:10.5012/bkcs.2011.32.12.4309

upstream raw materials:

1-(4-methoxy-benzyl)-5-methyl-1H-indole-2-carboxylic acid ethyl ester

[1-(4-methoxy-benzyl)-5-methyl-1H-indol-2-yl]-methanol

5-methyl-1H-indole-2-carboxylic acid ethyl ester

5-methyl-2-nitrobenzaldehyde

Downstream raw materials:

1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-5-methyl-hex-4-en-1-one