2-(4-fluorophenyl)-3-(pyrrole-1-carbonyl)-2H-quinoline-1-carboxylic acid benzyl ester

Base Information

Chemical Name:2-(4-fluorophenyl)-3-(pyrrole-1-carbonyl)-2H-quinoline-1-carboxylic acid benzyl ester
CAS No.:1357089-07-6
Molecular Formula:C₂₈H₂₁FN₂O₃
Molecular Weight:452.485
Hs Code.:

Synonyms:2-(4-fluorophenyl)-3-(pyrrole-1-carbonyl)-2H-quinoline-1-carboxylic acid benzyl ester

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Chemical Property of 2-(4-fluorophenyl)-3-(pyrrole-1-carbonyl)-2H-quinoline-1-carboxylic acid benzyl ester

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Technology Process of 2-(4-fluorophenyl)-3-(pyrrole-1-carbonyl)-2H-quinoline-1-carboxylic acid benzyl ester

There total 4 articles about 2-(4-fluorophenyl)-3-(pyrrole-1-carbonyl)-2H-quinoline-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: (2-formyl-phenyl)-carbamic acid benzyl ester

: 1201761-95-6
C₁₃H₁₀FNO

: 1357089-07-6
2-(4-fluorophenyl)-3-(pyrrole-1-carbonyl)-2H-quinoline-1-carboxylic acid benzyl ester

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); In acetonitrile; at 82 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.12.017

Reference yield:

: 5344-90-1
2-Aminobenzyl alcohol

: 1357089-07-6
2-(4-fluorophenyl)-3-(pyrrole-1-carbonyl)-2H-quinoline-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrahydrofuran; water / 0.5 h / 0 °C

2: pyridinium chlorochromate / dichloromethane / 2.5 h / 20 °C

3: copper(II) bis(trifluoromethanesulfonate) / acetonitrile / 48 h / 82 °C / Inert atmosphere

With copper(II) bis(trifluoromethanesulfonate); sodium carbonate; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water; acetonitrile; 3: Michael-aldol reaction;
DOI:10.1016/j.tetlet.2011.12.017

Reference yield:

: 111881-64-2
(2-hydroxymethyl-phenyl)-carbamic acid benzyl ester

: 1357089-07-6
2-(4-fluorophenyl)-3-(pyrrole-1-carbonyl)-2H-quinoline-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium chlorochromate / dichloromethane / 2.5 h / 20 °C

2: copper(II) bis(trifluoromethanesulfonate) / acetonitrile / 48 h / 82 °C / Inert atmosphere

With copper(II) bis(trifluoromethanesulfonate); pyridinium chlorochromate; In dichloromethane; acetonitrile; 2: Michael-aldol reaction;
DOI:10.1016/j.tetlet.2011.12.017