(3R,4S)-4-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-1-pentene

Base Information

Chemical Name:(3R,4S)-4-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-1-pentene
CAS No.:566203-44-9
Molecular Formula:C₁₉H₃₂O₃Si
Molecular Weight:336.547
Hs Code.:

Synonyms:(3R,4S)-4-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-1-pentene

Suppliers and Price of (3R,4S)-4-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-1-pentene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,4S)-4-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-1-pentene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,4S)-4-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-1-pentene

There total 1 articles about (3R,4S)-4-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-1-pentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 212051-17-7
4-methoxybenzyl 2,2,2-trifluoroacetimidate

: 132055-83-5
(3R,4S)-4-(tert-butyldimethylsilanyloxy)-pent-1-en-3-ol

: 566203-44-9
(3R,4S)-4-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-1-pentene

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/ol0350689

Reference yield: 96.0%

: 566203-44-9
(3R,4S)-4-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-1-pentene

: 566203-45-0
(3R,4S)-4-hydroxy-3-(4-methoxybenzyloxy)-1-pentene

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1021/ol0350689 DOI:10.1021/jo035435u

Reference yield:

: 566203-44-9
(3R,4S)-4-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-1-pentene

: 172923-77-2
(+)-macrosphelide A

Guidance literature:: Multi-step reaction with 9 steps

1: 96 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / 20 °C

2: 99 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-dimethylaminopyridine / CH₂Cl₂ / 0 - 20 °C

3: 95 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 5 h / 20 °C

4: 6.14 g / DMAP / toluene / 1 h

5: 85 percent / tetra-n-butylammonium fluoride; acetic acid / tetrahydrofuran / 120 h / 20 °C

6: 95 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

7: 65 percent / Cl₂Ru(=CHC₆H₅)(PCy₃)(1,3-Mes₂-imidazolidin-2-yl) / 1,2-dichloro-ethane / 120 h / 80 °C

8: 99 percent / DDQ / CH₂Cl₂; H₂O / 0.5 h / 20 °C

9: 90 percent / trifluoroacetic acid / CH₂Cl₂ / 0 - 20 °C

With dmap; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene](benzylidene)Ru(II) dichloride; tetrabutyl ammonium fluoride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; toluene;
DOI:10.1021/ol0350689