2-(3-amino-propylamino)-N-[benzofuran-2-yl-(4-chloro-phenyl)-methyl]-acetamide

Base Information

Chemical Name:2-(3-amino-propylamino)-N-[benzofuran-2-yl-(4-chloro-phenyl)-methyl]-acetamide
CAS No.:352285-42-8
Molecular Formula:C₂₀H₂₂ClN₃O₂
Molecular Weight:371.867
Hs Code.:

2-(3-amino-propylamino)-<i>N</i>-[benzofuran-2-yl-(4-chloro-phenyl)-methyl]-acetamide

Synonyms:2-(3-amino-propylamino)-N-[benzofuran-2-yl-(4-chloro-phenyl)-methyl]-acetamide

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Chemical Property of 2-(3-amino-propylamino)-N-[benzofuran-2-yl-(4-chloro-phenyl)-methyl]-acetamide

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Technology Process of 2-(3-amino-propylamino)-N-[benzofuran-2-yl-(4-chloro-phenyl)-methyl]-acetamide

There total 3 articles about 2-(3-amino-propylamino)-N-[benzofuran-2-yl-(4-chloro-phenyl)-methyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 352285-41-7
{3-[({[benzofuran-2-yl-(4-chloro-phenyl)-methyl]-carbamoyl}-methyl)-tert-butoxycarbonyl-amino]-propyl}-carbamic acid tert-butyl ester

: 352285-42-8
2-(3-amino-propylamino)-N-[benzofuran-2-yl-(4-chloro-phenyl)-methyl]-acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ja010249w

Reference yield:

: 192124-66-6
N,N'-bis(tert-butoxycarbonyl)-(3-aminopropyl)-glycine

: 352285-42-8
2-(3-amino-propylamino)-N-[benzofuran-2-yl-(4-chloro-phenyl)-methyl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: EDC; DMAP / CH₂Cl₂ / 0 - 20 °C

2: TFA / CH₂Cl₂ / 2 h / 20 °C

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ja010249w

Reference yield:

: 352284-59-4
N,N'-bis(tert-butoxycarbonyl)-(3-aminopropyl)-glycine ethyl ester

: 352285-42-8
2-(3-amino-propylamino)-N-[benzofuran-2-yl-(4-chloro-phenyl)-methyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / aq. KOH / methanol / 2 h / 20 °C

2: EDC; DMAP / CH₂Cl₂ / 0 - 20 °C

3: TFA / CH₂Cl₂ / 2 h / 20 °C

With dmap; potassium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1021/ja010249w