3-(3',6-dimethoxy-[1,1'-biphenyl]-3-ylcarboxamido)-8-methoxy-2-oxo-2H-chromen-7-yl acetate

Base Information

Chemical Name:3-(3',6-dimethoxy-[1,1'-biphenyl]-3-ylcarboxamido)-8-methoxy-2-oxo-2H-chromen-7-yl acetate
CAS No.:1160952-43-1
Molecular Formula:C₂₇H₂₃NO₈
Molecular Weight:489.482
Hs Code.:

Synonyms:3-(3',6-dimethoxy-[1,1'-biphenyl]-3-ylcarboxamido)-8-methoxy-2-oxo-2H-chromen-7-yl acetate

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Chemical Property of 3-(3',6-dimethoxy-[1,1'-biphenyl]-3-ylcarboxamido)-8-methoxy-2-oxo-2H-chromen-7-yl acetate

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Technology Process of 3-(3',6-dimethoxy-[1,1'-biphenyl]-3-ylcarboxamido)-8-methoxy-2-oxo-2H-chromen-7-yl acetate

There total 5 articles about 3-(3',6-dimethoxy-[1,1'-biphenyl]-3-ylcarboxamido)-8-methoxy-2-oxo-2H-chromen-7-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1083313-80-7
3',6-dimethoxy-[1,1'-biphenyl]-3-carbonyl chloride

: 1308889-59-9
C₁₂H₁₁NO₅

: 1160952-43-1
3-(3',6-dimethoxy-[1,1'-biphenyl]-3-ylcarboxamido)-8-methoxy-2-oxo-2H-chromen-7-yl acetate

Guidance literature:: With triethylamine; In tetrahydrofuran; for 12h;
DOI:10.1021/jm200148p

Reference yield: 46.0%

: 1083313-05-6
3′,6-dimethoxy-[1,1′-biphenyl]-3-carboxylic acid

: 1308889-59-9
C₁₂H₁₁NO₅

: 1160952-43-1
3-(3',6-dimethoxy-[1,1'-biphenyl]-3-ylcarboxamido)-8-methoxy-2-oxo-2H-chromen-7-yl acetate

Guidance literature:: 3',6-dimethoxy-[1,1'-biphenyl]-3-carboxylic acid; 3-amino-8-methoxy-2-oxo-2H-benzopyran-7-yl acetate; In acetonitrile; at 20 ℃; for 0.5h;

With phosphorus trichloride; In acetonitrile; at 0 ℃; Reflux;

Reference yield:

: 1083312-86-0
benzyl 7-hydroxy-8-methoxy-2-oxo-2H-chromen-3-ylcarbamate

: 1160952-43-1
3-(3',6-dimethoxy-[1,1'-biphenyl]-3-ylcarboxamido)-8-methoxy-2-oxo-2H-chromen-7-yl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 12 h

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 12 h

3: triethylamine / tetrahydrofuran / 12 h

With palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; pyridine;
DOI:10.1021/jm200148p