(1R,2R)-N-(2-hydroxy-1-hydroxymethyl-2-methyl-but-3-ynyl)-2-nitrobenzenesulfonamide

Base Information

Chemical Name:(1R,2R)-N-(2-hydroxy-1-hydroxymethyl-2-methyl-but-3-ynyl)-2-nitrobenzenesulfonamide
CAS No.:870137-19-2
Molecular Formula:C₁₂H₁₄N₂O₆S
Molecular Weight:314.319
Hs Code.:

Synonyms:(1R,2R)-N-(2-hydroxy-1-hydroxymethyl-2-methyl-but-3-ynyl)-2-nitrobenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R)-N-(2-hydroxy-1-hydroxymethyl-2-methyl-but-3-ynyl)-2-nitrobenzenesulfonamide

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Technology Process of (1R,2R)-N-(2-hydroxy-1-hydroxymethyl-2-methyl-but-3-ynyl)-2-nitrobenzenesulfonamide

There total 4 articles about (1R,2R)-N-(2-hydroxy-1-hydroxymethyl-2-methyl-but-3-ynyl)-2-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 870137-18-1
(R)-4-((R)-1-hydroxy-1-methylprop-2-ynyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 870137-19-2
(1R,2R)-N-(2-hydroxy-1-hydroxymethyl-2-methyl-but-3-ynyl)-2-nitrobenzenesulfonamide

: 960595-71-5
(2R,3S)-3-methyl-2-(2-nitrobenzenesulfonylamino)-pent-4-yne-1,3-diol

Guidance literature:: (R)-4-((R)-1-hydroxy-1-methylprop-2-ynyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester; With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 1h;

2-Nitrobenzenesulfonyl chloride; With sodium carbonate; In tetrahydrofuran; water; at 20 ℃; Further stages.;
DOI:10.1021/ja710363p

Reference yield: 86.0%

: (4R)-4-(2-hydroxybut-3-yn-2-yl)-2,2-dimethyl-3-(tert-butoxycarbonyl)-oxazolidine

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 870137-19-2
(1R,2R)-N-(2-hydroxy-1-hydroxymethyl-2-methyl-but-3-ynyl)-2-nitrobenzenesulfonamide

Guidance literature:: (4R)-4-(2-hydroxybut-3-yn-2-yl)-2,2-dimethyl-3-(tert-butoxycarbonyl)-oxazolidine; With hydrogenchloride; In dichloromethane; acetonitrile; for 1.5h;

2-Nitrobenzenesulfonyl chloride; With magnesium oxide; In tetrahydrofuran; water; for 2h; Further stages.;
DOI:10.1002/anie.200702537