Phenol, 2-fluoro-3-methoxy-5-methyl- (9CI)

Base Information

• Chemical Name: Phenol, 2-fluoro-3-methoxy-5-methyl- (9CI)
• CAS No.: 447462-92-2
• Molecular Formula: C8H9 F O2
• Molecular Weight: 156.1542632
• Mol file: 447462-92-2.mol

Synonyms:Phenol, 2-fluoro-3-methoxy-5-methyl- (9CI)

Chemical Property of Phenol, 2-fluoro-3-methoxy-5-methyl- (9CI)

Chemical Property:

• PSA: 29.46000
• LogP: 1.84830

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenol, 2-fluoro-3-methoxy-5-methyl- (9CI)

There total 4 articles about Phenol, 2-fluoro-3-methoxy-5-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,6-difluoro-5-methoxy-3-methylcyclohexa-2,4-dienone (1256550-28-3) → 2-fluoro-3-methoxy-5-methylphenol (447462-92-2)

Guidance literature:

With sodium tetrahydroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; at 0 - 80 ℃;

DOI:10.1021/ol200808q

Reference yield:

3-methoxy-5-methylbenzene-1,2-diol (1125-67-3) → 2-fluoro-3-methoxy-5-methylphenol (447462-92-2)

Guidance literature:

Multi-step reaction with 3 steps

1: [bis(acetoxy)iodo]benzene; magnesium oxide / chloroform / 0 - 20 °C

2: (bis-(2-methoxyethyl)amino)sulfur trufluoride / chloroform / 0 - 20 °C / Inert atmosphere

3: sodium tetrahydroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 0 - 80 °C

With sodium tetrahydroborate; [bis(acetoxy)iodo]benzene; magnesium oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In ethanol; chloroform;

DOI:10.1021/ol200808q

Reference yield:

3-methoxy-5-methyl-[1,2]benzoquinone (60824-63-7) → 2-fluoro-3-methoxy-5-methylphenol (447462-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / chloroform / 0 - 20 °C / Inert atmosphere

2: sodium tetrahydroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 0 - 80 °C

With sodium tetrahydroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In ethanol; chloroform;

DOI:10.1021/ol200808q

upstream raw materials:

1-fluoro-2-methoxy-4-methylbenzene

6,6-difluoro-5-methoxy-3-methylcyclohexa-2,4-dienone

3-methoxy-5-methylbenzene-1,2-diol

3-methoxy-5-methyl-[1,2]benzoquinone

Refernces

• 1、 Pirrung, Michael C.,Park, Kaapjoo. "Discovery of selective metal-binding peptoids using 19F encoded combinatorial libraries". . p. 2115 - 2118. Retrieved 2007/10/03.