4-(4-fluoro-2-hydroxymethylphenyl)piperidine-1-carboxylic acid t-butyl ester

Base Information

Chemical Name:4-(4-fluoro-2-hydroxymethylphenyl)piperidine-1-carboxylic acid t-butyl ester
CAS No.:1227304-58-6
Molecular Formula:C₁₇H₂₄FNO₃
Molecular Weight:309.381
Hs Code.:

Synonyms:4-(4-fluoro-2-hydroxymethylphenyl)piperidine-1-carboxylic acid t-butyl ester

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Chemical Property of 4-(4-fluoro-2-hydroxymethylphenyl)piperidine-1-carboxylic acid t-butyl ester

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Technology Process of 4-(4-fluoro-2-hydroxymethylphenyl)piperidine-1-carboxylic acid t-butyl ester

There total 1 articles about 4-(4-fluoro-2-hydroxymethylphenyl)piperidine-1-carboxylic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227304-60-0
C₁₈H₂₄FNO₄

: 1227304-58-6
4-(4-fluoro-2-hydroxymethylphenyl)piperidine-1-carboxylic acid t-butyl ester

Guidance literature:: C₁₈H₂₄FNO₄; With dimethyl sulfide borane; In tetrahydrofuran; at 20 ℃; Reflux;

With methanol; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1227304-58-6
4-(4-fluoro-2-hydroxymethylphenyl)piperidine-1-carboxylic acid t-butyl ester

: 2268-17-9
2,4,6-trifluorophenol

: 76-05-1
trifluoroacetic acid

: 1227304-32-6
4-[4-fluoro-2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine trifluoroacetate

Guidance literature:: 4-(4-fluoro-2-hydroxymethylphenyl)piperidine-1-carboxylic acid t-butyl ester; 2,4,6-trifluorophenol; With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 80 ℃; for 4h;

With hydrogenchloride; In ethanol; at 20 ℃;

trifluoroacetic acid;