methyl 4-[3-(5-chloro-1-(diphenylmethyl)-2-{2-[(vinylsulfonyl)amino]ethyl}-1H-indol-3-yl)propyl]benzoate

Base Information

• Chemical Name: methyl 4-[3-(5-chloro-1-(diphenylmethyl)-2-{2-[(vinylsulfonyl)amino]ethyl}-1H-indol-3-yl)propyl]benzoate
• CAS No.: 1002987-04-3
• Molecular Formula: C₃₆H₃₅ClN₂O₄S
• Molecular Weight: 627.204

Synonyms:methyl 4-[3-(5-chloro-1-(diphenylmethyl)-2-{2-[(vinylsulfonyl)amino]ethyl}-1H-indol-3-yl)propyl]benzoate

Chemical Property of methyl 4-[3-(5-chloro-1-(diphenylmethyl)-2-{2-[(vinylsulfonyl)amino]ethyl}-1H-indol-3-yl)propyl]benzoate

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Technology Process of methyl 4-[3-(5-chloro-1-(diphenylmethyl)-2-{2-[(vinylsulfonyl)amino]ethyl}-1H-indol-3-yl)propyl]benzoate

There total 1 articles about methyl 4-[3-(5-chloro-1-(diphenylmethyl)-2-{2-[(vinylsulfonyl)amino]ethyl}-1H-indol-3-yl)propyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

methyl 4-{3-[2-(2-aminoethyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoate (540522-70-1) + 2-Chloroethanesulfonyl chloride (1622-32-8) → methyl 4-[3-(5-chloro-1-(diphenylmethyl)-2-{2-[(vinylsulfonyl)amino]ethyl}-1H-indol-3-yl)propyl]benzoate (1002987-04-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm8009876

Reference yield: 100.0%

3,5-dimethyl-1H-pyrazole (67-51-6) + methyl 4-[3-(5-chloro-1-(diphenylmethyl)-2-{2-[(vinylsulfonyl)amino]ethyl}-1H-indol-3-yl)propyl]benzoate (1002987-04-3) → methyl 4-(3-{1-benzhydryl-5-chloro-2-[2-({[2-(3,5-dimethyl-1Hpyrazol-1-yl)ethyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}propyl)benzoate (960132-66-5)

Guidance literature:

In ethanol; at 20 ℃;

DOI:10.1021/jm8009876

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + methyl 4-[3-(5-chloro-1-(diphenylmethyl)-2-{2-[(vinylsulfonyl)amino]ethyl}-1H-indol-3-yl)propyl]benzoate (1002987-04-3) → methyl 4-(3-{1-benzhydryl-5-chloro-2-[2-({[2-(4-morpholinyl)ethyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}propyl)benzoate (1125598-46-0)

Guidance literature:

In ethanol; at 20 ℃;

DOI:10.1021/jm8009876

upstream raw materials:

methyl 4-{3-[2-(2-aminoethyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoate

2-Chloroethanesulfonyl chloride

Downstream raw materials:

methyl 4-(3-{1-benzhydryl-5-chloro-2-[2-({[2-(4-morpholinyl)ethyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}propyl)benzoate

methyl 4-(3-{1-benzhydryl-5-chloro-2-[2-({[2-(3,5-dimethyl-1Hpyrazol-1-yl)ethyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}propyl)benzoate

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