3-amino-1-(3-fluorophenyl)-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester

Base Information

Chemical Name:3-amino-1-(3-fluorophenyl)-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester
CAS No.:1201495-83-1
Molecular Formula:C₁₈H₂₁FN₂O₄
Molecular Weight:348.374
Hs Code.:

Synonyms:3-amino-1-(3-fluorophenyl)-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-amino-1-(3-fluorophenyl)-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester

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Technology Process of 3-amino-1-(3-fluorophenyl)-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester

There total 1 articles about 3-amino-1-(3-fluorophenyl)-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: (3-fluorophenylamino)-acetic acid tert-butyl ester

: 94-05-3,42466-69-3
ethyl (ethoxymethylene)cyanoacetate

: 1201495-83-1
3-amino-1-(3-fluorophenyl)-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 110 - 120 ℃; Inert atmosphere;

Reference yield: 74.0%

: 1201495-83-1
3-amino-1-(3-fluorophenyl)-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester

: 624-83-9
methyl isocyanate

: 1201496-07-2
1-(3-fluorophenyl)-4-(3-methyl-ureido)-1H-pyrrole-3-carboxylic acid ethyl ester

Guidance literature:: 3-amino-1-(3-fluorophenyl)-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester; With trifluoroacetic acid; at 20 ℃;

methyl isocyanate; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

In dichloromethane;

Reference yield: 74.0%

: 1201495-83-1
3-amino-1-(3-fluorophenyl)-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester

: 3019-71-4
Trichloroacetyl isocyanate

: 1201495-95-5
1-(3-fluorophenyl)-4-ureido-1H-pyrrole-3-carboxylic acid ethyl ester

Guidance literature:: 3-amino-1-(3-fluorophenyl)-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester; With trifluoroacetic acid; at 20 ℃;

Trichloroacetyl isocyanate; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

With ammonia; In methanol; at 20 ℃;