(S)-N-(3-hydroxyphenyl)-4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide

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Chemical Name:(S)-N-(3-hydroxyphenyl)-4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide
CAS No.:1605327-00-1
Molecular Formula:C₂₈H₂₄N₈O₃
Molecular Weight:520.55
Hs Code.:

Synonyms:(S)-N-(3-hydroxyphenyl)-4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide

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Chemical Property of (S)-N-(3-hydroxyphenyl)-4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide

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Technology Process of (S)-N-(3-hydroxyphenyl)-4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide

There total 11 articles about (S)-N-(3-hydroxyphenyl)-4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 1605330-92-4
(S)-4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid

: 591-27-5
m-Hydroxyaniline

: 1605327-00-1
(S)-N-(3-hydroxyphenyl)-4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide

Guidance literature:: (S)-4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid; m-Hydroxyaniline; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In N,N-dimethyl-formamide; at 20 ℃; Sealed tube;

Reference yield:

: 1133931-03-9
C₆H₆ClNO

: 1605327-00-1
(S)-N-(3-hydroxyphenyl)-4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

2.1: Aliquat 336; sodium hypochlorite; ammonium chloride; ammonium hydroxide; sodium hydroxide / water; diethyl ether; tert-butyl methyl ether / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 0 - 20 °C

4.1: triethylamine; triphenylphosphine; bromine / dichloromethane / 2 h / 60 °C

5.1: ammonia / methanol / 32 h / 100 °C

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 12 h / 80 °C

8.1: hydrogen; palladium 10% on activated carbon / methanol / 1292.9 Torr

9.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h

9.2: 20 °C

With ammonium hydroxide; sodium hypochlorite; palladium 10% on activated carbon; ammonia; hydrogen; bromine; Aliquat 336; ammonium chloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In methanol; diethyl ether; dichloromethane; tert-butyl methyl ether; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/acs.jmedchem.8b00873

Reference yield:

: 62-53-3
aniline

: 1605327-00-1
(S)-N-(3-hydroxyphenyl)-4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

2.1: Aliquat 336; sodium hypochlorite; ammonium chloride; ammonium hydroxide; sodium hydroxide / water; diethyl ether; tert-butyl methyl ether / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 0 - 20 °C

4.1: triethylamine; triphenylphosphine; bromine / dichloromethane / 2 h / 60 °C

5.1: ammonia / methanol / 32 h / 100 °C

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 12 h / 80 °C

8.1: hydrogen; palladium 10% on activated carbon / methanol / 1292.9 Torr

9.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h

9.2: 20 °C

With ammonium hydroxide; sodium hypochlorite; palladium 10% on activated carbon; ammonia; hydrogen; bromine; Aliquat 336; ammonium chloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In methanol; diethyl ether; dichloromethane; tert-butyl methyl ether; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/acs.jmedchem.8b00873