3-(3-Fluoro-phenoxy)-phenylamine

Base Information

• Chemical Name: 3-(3-Fluoro-phenoxy)-phenylamine
• CAS No.: 446884-28-2
• Molecular Formula: C12H10 F N O
• Molecular Weight: 203.216
• DSSTox Substance ID: DTXSID80477458
• Mol file: 446884-28-2.mol

Synonyms:446884-28-2;3-(3-FLUORO-PHENOXY)-PHENYLAMINE;SCHEMBL5492733;DTXSID80477458;1-(3-Aminophenoxy)-3-fluorobenzene;AKOS017559736

Chemical Property of 3-(3-Fluoro-phenoxy)-phenylamine

Chemical Property:

• Boiling Point: 312.8±22.0 °C(Predicted)
• PKA: 3.91±0.10(Predicted)
• PSA: 35.25000
• Density: 1.220±0.06 g/cm3(Predicted)
• LogP: 3.78140
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 203.074642105
• Heavy Atom Count: 15
• Complexity: 200

Purity/Quality:

99%+ ^*data from raw suppliers

3-(3-fluoro-phenoxy)-phenylamine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)OC2=CC(=CC=C2)F)N

Technology Process of 3-(3-Fluoro-phenoxy)-phenylamine

There total 1 articles about 3-(3-Fluoro-phenoxy)-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Fluoro-3-iodobenzene (1121-86-4) + m-Hydroxyaniline (591-27-5) → 3-(3-fluorophenoxy)aniline (446884-28-2)

Guidance literature:

With 2-Picolinic acid; potassium phosphate; copper(l) iodide; In dimethyl sulfoxide; at 90 ℃; for 24h; Inert atmosphere;

Reference yield: 66.0%

3-(3-fluorophenoxy)aniline (446884-28-2) + (E)-2-(ethoxymethylene)malonate 1-ethyl 3-propyl ester → propyl 7-(3-fluorophenoxy)-4-hydroxyquinoline-3-carboxylate

Guidance literature:

In ethanol; at 90 ℃; for 3h;

Reference yield: 66.0%

3-(3-fluorophenoxy)aniline (446884-28-2) + (E)-1-butyl 3-ethyl 2-(ethoxymethylene)malonate → butyl 7-(3-fluorophenoxy)-4-hydroxyquinoline-3-carboxylate

Guidance literature:

In ethanol; at 90 - 100 ℃; for 3.5h;

upstream raw materials:

1-Fluoro-3-iodobenzene

m-Hydroxyaniline

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