N-({(1S,2S,5R)-3-[(2-methyl-5-phenyl-1,3-thiazol-4-yl)carbonyl]-3-azabicyclo[3.1.0]hex-2-yl}methyl)-1,3-benzoxazol-2-amine

Base Information

Chemical Name:N-({(1S,2S,5R)-3-[(2-methyl-5-phenyl-1,3-thiazol-4-yl)carbonyl]-3-azabicyclo[3.1.0]hex-2-yl}methyl)-1,3-benzoxazol-2-amine
CAS No.:1092504-90-9
Molecular Formula:C₂₄H₂₂N₄O₂S
Molecular Weight:430.53
Hs Code.:

Synonyms:N-({(1S,2S,5R)-3-[(2-methyl-5-phenyl-1,3-thiazol-4-yl)carbonyl]-3-azabicyclo[3.1.0]hex-2-yl}methyl)-1,3-benzoxazol-2-amine

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Chemical Property of N-({(1S,2S,5R)-3-[(2-methyl-5-phenyl-1,3-thiazol-4-yl)carbonyl]-3-azabicyclo[3.1.0]hex-2-yl}methyl)-1,3-benzoxazol-2-amine

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Technology Process of N-({(1S,2S,5R)-3-[(2-methyl-5-phenyl-1,3-thiazol-4-yl)carbonyl]-3-azabicyclo[3.1.0]hex-2-yl}methyl)-1,3-benzoxazol-2-amine

There total 12 articles about N-({(1S,2S,5R)-3-[(2-methyl-5-phenyl-1,3-thiazol-4-yl)carbonyl]-3-azabicyclo[3.1.0]hex-2-yl}methyl)-1,3-benzoxazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 1092504-90-9
N-({(1S,2S,5R)-3-[(2-methyl-5-phenyl-1,3-thiazol-4-yl)carbonyl]-3-azabicyclo[3.1.0]hex-2-yl}methyl)-1,3-benzoxazol-2-amine

Guidance literature:: Multi-step reaction with 11 steps

1.1: triethylamine / dmap / dichloromethane / 24 h

2.1: dmap / acetonitrile / 12 h / 20 °C

3.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hexamethyldisilazane / tetrahydrofuran / 0.83 h / 0 - 78 °C

3.2: 2 h / -78 °C

4.1: dihydrogen peroxide / tetrahydrofuran; water / 2 h / 0 °C

5.1: diazomethane / palladium diacetate / diethyl ether / 2 h / 0 °C

6.1: borane-THF / tetrahydrofuran / 15 h / 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 2 h

7.2: 15 h / 20 °C

8.1: triethylamine / dichloromethane / 0.5 h / 20 °C

9.1: sodium azide / N,N-dimethyl-formamide / 1 h / 60 °C

10.1: polymer-bound triphenylphosphine; water / tetrahydrofuran / 12 h / 20 °C

11.1: triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 65 °C

With diazomethane; hydrogenchloride; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium azide; borane-THF; polymer-bound triphenylphosphine; water; dihydrogen peroxide; sodium hexamethyldisilazane; triethylamine; dmap; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 615-18-9
2-chloro-1,3-benzoxazole

: 1092506-44-9
C₁₇H₁₉N₃OS

: 1092504-90-9
N-({(1S,2S,5R)-3-[(2-methyl-5-phenyl-1,3-thiazol-4-yl)carbonyl]-3-azabicyclo[3.1.0]hex-2-yl}methyl)-1,3-benzoxazol-2-amine

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 - 65 ℃; for 3h;

Reference yield:

: 81658-26-6
tert-butyl (S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-oxopyrrolidin-1-carboxylate

: 1092504-90-9
N-({(1S,2S,5R)-3-[(2-methyl-5-phenyl-1,3-thiazol-4-yl)carbonyl]-3-azabicyclo[3.1.0]hex-2-yl}methyl)-1,3-benzoxazol-2-amine

Guidance literature:: Multi-step reaction with 9 steps

1.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hexamethyldisilazane / tetrahydrofuran / 0.83 h / 0 - 78 °C

1.2: 2 h / -78 °C

2.1: dihydrogen peroxide / tetrahydrofuran; water / 2 h / 0 °C

3.1: diazomethane / palladium diacetate / diethyl ether / 2 h / 0 °C

4.1: borane-THF / tetrahydrofuran / 15 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2 h

5.2: 15 h / 20 °C

6.1: triethylamine / dichloromethane / 0.5 h / 20 °C

7.1: sodium azide / N,N-dimethyl-formamide / 1 h / 60 °C

8.1: polymer-bound triphenylphosphine; water / tetrahydrofuran / 12 h / 20 °C

9.1: triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 65 °C

With diazomethane; hydrogenchloride; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium azide; borane-THF; polymer-bound triphenylphosphine; water; dihydrogen peroxide; sodium hexamethyldisilazane; triethylamine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;