(S)-2-[2-methyl-1-(tritylamino)propyl]-thiazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:(S)-2-[2-methyl-1-(tritylamino)propyl]-thiazole-4-carboxylic acid ethyl ester
CAS No.:946851-44-1
Molecular Formula:C₂₉H₃₀N₂O₂S
Molecular Weight:470.635
Hs Code.:

Synonyms:(S)-2-[2-methyl-1-(tritylamino)propyl]-thiazole-4-carboxylic acid ethyl ester

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Chemical Property of (S)-2-[2-methyl-1-(tritylamino)propyl]-thiazole-4-carboxylic acid ethyl ester

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Technology Process of (S)-2-[2-methyl-1-(tritylamino)propyl]-thiazole-4-carboxylic acid ethyl ester

There total 5 articles about (S)-2-[2-methyl-1-(tritylamino)propyl]-thiazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76-83-5
trityl chloride

: 220717-59-9
2-<(S)-1-amino-2-methylpropyl>-4-ethoxycarbonylthiazole

: 946851-44-1
(S)-2-[2-methyl-1-(tritylamino)propyl]-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: With triethylamine; In 1,2-dimethoxyethane; at 25 ℃; for 16h;
DOI:10.1002/anie.200700684

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 946851-44-1
(S)-2-[2-methyl-1-(tritylamino)propyl]-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 96 percent / isobutyl chloroformate; N-methylmorpholine; aq. NH₃ / tetrahydrofuran / 16 h / -20 - 25 °C

2.1: 82 percent / Lawesson reagent / tetrahydrofuran / 16 h / 25 °C

3.1: KHCO₃ / 1,2-dimethoxy-ethane / 24 h / -15 °C

3.2: trifluoroacetic anhydride; pyridine / 1,2-dimethoxy-ethane / 2 h / -15 °C

4.1: trifluoroacetic acid / CH₂Cl₂

5.1: NEt₃ / 1,2-dimethoxy-ethane / 16 h / 25 °C

With Lawessons reagent; 4-methyl-morpholine; ammonium hydroxide; potassium hydrogencarbonate; triethylamine; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 3.2: Hantzsch synthesis;
DOI:10.1002/anie.200700684

Reference yield:

: 35150-08-4
Boc-Val-NH₂

: 946851-44-1
(S)-2-[2-methyl-1-(tritylamino)propyl]-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / Lawesson reagent / tetrahydrofuran / 16 h / 25 °C

2.1: KHCO₃ / 1,2-dimethoxy-ethane / 24 h / -15 °C

2.2: trifluoroacetic anhydride; pyridine / 1,2-dimethoxy-ethane / 2 h / -15 °C

3.1: trifluoroacetic acid / CH₂Cl₂

4.1: NEt₃ / 1,2-dimethoxy-ethane / 16 h / 25 °C

With Lawessons reagent; potassium hydrogencarbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 2.2: Hantzsch synthesis;
DOI:10.1002/anie.200700684