methyl 3α-bromoacetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate

Base Information

• Chemical Name: methyl 3α-bromoacetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate
• CAS No.: 648928-23-8
• Molecular Formula: C₄₁H₅₅BrN₄O₆
• Molecular Weight: 779.815
• Mol file: 648928-23-8.mol

Synonyms:methyl 3α-bromoacetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate

Chemical Property of methyl 3α-bromoacetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3α-bromoacetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate

There total 3 articles about methyl 3α-bromoacetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 3α-chloroacetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate (648928-13-6) → methyl 3α-bromoacetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate (648928-23-8)

Guidance literature:

With sodium bromide; In acetone; for 19h; Heating;

DOI:10.1021/ja029670q

Reference yield:

methyl 3α-hydroxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate (648928-06-7) → methyl 3α-bromoacetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate (648928-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / EDC; DMAP / CH₂Cl₂ / 18 h / 20 °C

2: 99 percent / NaBr / acetone / 19 h / Heating

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium bromide; In dichloromethane; acetone;

DOI:10.1021/ja029670q

Reference yield:

methyl 3α-acetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate (437613-66-6) → methyl 3α-bromoacetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate (648928-23-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / aq. HCl / methanol / 12 h / 20 °C

2: 76 percent / EDC; DMAP / CH₂Cl₂ / 18 h / 20 °C

3: 99 percent / NaBr / acetone / 19 h / Heating

With hydrogenchloride; dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium bromide; In methanol; dichloromethane; acetone;

DOI:10.1021/ja029670q

upstream raw materials:

methyl 3α-chloroacetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate

methyl 3α-hydroxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate

methyl 3α-acetoxy-7α,12α-di[(phenylaminocarbonyl)amino]-5β-cholan-24-oate