N-benzenesulfonyl-D,L-leucyl-L-prolyl-[(4-amidinophenyl)methyl]amide acetate

Base Information

Chemical Name:N-benzenesulfonyl-D,L-leucyl-L-prolyl-[(4-amidinophenyl)methyl]amide acetate
CAS No.:1374962-09-0
Molecular Formula:C₂H₄O₂*C₂₅H₃₃N₅O₄S
Molecular Weight:559.687
Hs Code.:

Synonyms:N-benzenesulfonyl-D,L-leucyl-L-prolyl-[(4-amidinophenyl)methyl]amide acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-benzenesulfonyl-D,L-leucyl-L-prolyl-[(4-amidinophenyl)methyl]amide acetate

Chemical Property:

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Technology Process of N-benzenesulfonyl-D,L-leucyl-L-prolyl-[(4-amidinophenyl)methyl]amide acetate

There total 6 articles about N-benzenesulfonyl-D,L-leucyl-L-prolyl-[(4-amidinophenyl)methyl]amide acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1374962-07-8
C₂₅H₃₃N₅O₅S

: 64-19-7,77671-22-8
acetic acid

: 1374962-09-0
N-benzenesulfonyl-D,L-leucyl-L-prolyl-[(4-amidinophenyl)methyl]amide acetate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; acetic anhydride; for 24h;

Reference yield:

: 68305-76-0,1374962-72-7
N-benzenesulfonyl-D,L-leucine

: 1374962-09-0
N-benzenesulfonyl-D,L-leucyl-L-prolyl-[(4-amidinophenyl)methyl]amide acetate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C / Inert atmosphere; Cooling

2: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5.33 h / 0 - 20 °C / Inert atmosphere

4: hydroxylamine hydrochloride; sodium carbonate / water; ethanol / 2 h / Inert atmosphere; Reflux

5: palladium 10% on activated carbon; hydrogen; acetic anhydride / 24 h

With palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; acetic anhydride; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; water;

Reference yield:

: 1374962-73-8
N-benzenesulfonyl-D,L-leucyl-L-proline benzyl ester

: 1374962-09-0
N-benzenesulfonyl-D,L-leucyl-L-prolyl-[(4-amidinophenyl)methyl]amide acetate

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5.33 h / 0 - 20 °C / Inert atmosphere

3: hydroxylamine hydrochloride; sodium carbonate / water; ethanol / 2 h / Inert atmosphere; Reflux

4: palladium 10% on activated carbon; hydrogen; acetic anhydride / 24 h

With palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; acetic anhydride; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; water;