C₁₈H₁₀BrNO₂

Base Information

Chemical Name:C₁₈H₁₀BrNO₂
CAS No.:1300033-82-2
Molecular Formula:C₁₈H₁₀BrNO₂
Molecular Weight:352.187
Hs Code.:

C<sub>18</sub>H<sub>10</sub>BrNO<sub>2</sub>

Synonyms:C₁₈H₁₀BrNO₂

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Chemical Property of C₁₈H₁₀BrNO₂

Chemical Property:

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Technology Process of C₁₈H₁₀BrNO₂

There total 1 articles about C₁₈H₁₀BrNO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 30186-18-6
4'-bromo-2'-hydroxyacetophenone

: 27104-73-0
methyl isoquinoline-3-carboxylate

: 1300033-82-2
C₁₈H₁₀BrNO₂

Guidance literature:: 4'-bromo-2'-hydroxyacetophenone; methyl isoquinoline-3-carboxylate; With pyridine; sodium hydride; In mineral oil; at 90 ℃; for 1h;

With sulfuric acid; acetic acid; at 110 ℃; for 1h;
DOI:10.1021/acs.jmedchem.7b00991

Reference yield:

: 1300033-82-2
C₁₈H₁₀BrNO₂

: 1300033-91-3
2-isoquinolin-3-yl-7-phenylethynyl-chromen-4-one O-tert-butyl oxime

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 12 h / 120 °C / Sealed tube

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In ethanol; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.7b00991

Reference yield:

: 1300033-82-2
C₁₈H₁₀BrNO₂

: 1300033-90-2
2-isoquinolin-3-yl-7-phenethyl-chromen-4-one O-tert-butyl oxime

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 12 h / 120 °C / Sealed tube

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

3: hydrogen / methanol; tetrahydrofuran / 5 h / 20 °C / 760.05 Torr / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; triethylamine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.7b00991