{1-[3-(1-methylbenzimidazol-2-yl)phenyl]piperidin-4-yl}-(4-methypiperazin-1-yl)methanone hydrobromide

Base Information

Chemical Name:{1-[3-(1-methylbenzimidazol-2-yl)phenyl]piperidin-4-yl}-(4-methypiperazin-1-yl)methanone hydrobromide
CAS No.:1612250-71-1
Molecular Formula:BrH*C₂₅H₃₁N₅O
Molecular Weight:498.466
Hs Code.:

Synonyms:{1-[3-(1-methylbenzimidazol-2-yl)phenyl]piperidin-4-yl}-(4-methypiperazin-1-yl)methanone hydrobromide

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Chemical Property of {1-[3-(1-methylbenzimidazol-2-yl)phenyl]piperidin-4-yl}-(4-methypiperazin-1-yl)methanone hydrobromide

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Technology Process of {1-[3-(1-methylbenzimidazol-2-yl)phenyl]piperidin-4-yl}-(4-methypiperazin-1-yl)methanone hydrobromide

There total 6 articles about {1-[3-(1-methylbenzimidazol-2-yl)phenyl]piperidin-4-yl}-(4-methypiperazin-1-yl)methanone hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 109-01-3
1-methyl-piperazine

: 1-[3-(1-methylbenzimidazol-2-yl)phenyl]piperidine-4-carboxylic acid

: 1612250-71-1
{1-[3-(1-methylbenzimidazol-2-yl)phenyl]piperidin-4-yl}-(4-methypiperazin-1-yl)methanone hydrobromide

Guidance literature:: 1-[3-(1-methylbenzimidazol-2-yl)phenyl]piperidine-4-carboxylic acid; With 1,1'-carbonyldiimidazole; In acetonitrile; at 50 ℃; for 1h; Inert atmosphere;

1-methyl-piperazine; In acetonitrile; at 55 ℃; for 2h; Inert atmosphere;

With hydrogen bromide; In water; acetonitrile; at 20 ℃; for 3.5h; Solvent; Reagent/catalyst;
DOI:10.1021/op4002092

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1612250-71-1
{1-[3-(1-methylbenzimidazol-2-yl)phenyl]piperidin-4-yl}-(4-methypiperazin-1-yl)methanone hydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogensulfite / water / 0.33 h / Inert atmosphere

1.2: 18 h / 70 °C / Inert atmosphere

2.1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 3 h / 100 °C / Inert atmosphere

3.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 70 °C / Inert atmosphere

4.1: 1,1'-carbonyldiimidazole / acetonitrile / 1 h / 50 °C / Inert atmosphere

4.2: 2 h / 55 °C / Inert atmosphere

4.3: 3.5 h / 20 °C

With water; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydrogensulfite; 1,1'-carbonyldiimidazole; sodium hydroxide; In 1,4-dioxane; water; toluene; acetonitrile; 2.1: |Buchwald-Hartwig Coupling;
DOI:10.1021/op4002092

Reference yield:

: 95-54-5
1,2-diamino-benzene

: 1612250-71-1
{1-[3-(1-methylbenzimidazol-2-yl)phenyl]piperidin-4-yl}-(4-methypiperazin-1-yl)methanone hydrobromide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogensulfite / water / 0.33 h / 20 - 25 °C / Inert atmosphere

1.2: 3 h / 70 °C / Inert atmosphere

2.1: potassium carbonate / acetone / 18 h / 35 °C

3.1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 3 h / 100 °C / Inert atmosphere

4.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 70 °C / Inert atmosphere

5.1: 1,1'-carbonyldiimidazole / acetonitrile / 1 h / 50 °C / Inert atmosphere

5.2: 2 h / 55 °C / Inert atmosphere

5.3: 3.5 h / 20 °C

With water; palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydrogensulfite; 1,1'-carbonyldiimidazole; sodium hydroxide; In 1,4-dioxane; water; acetone; toluene; acetonitrile; 3.1: |Buchwald-Hartwig Coupling;
DOI:10.1021/op4002092