2-Piperidinone, 3,4-dihydroxy-1-methyl-4-(4-pyridinyl)- (9CI)

Base Information

• Chemical Name: 2-Piperidinone, 3,4-dihydroxy-1-methyl-4-(4-pyridinyl)- (9CI)
• CAS No.: 446027-96-9
• Molecular Formula: C₁₁H₁₄N₂O₃
• Molecular Weight: 222.244
• Mol file: 446027-96-9.mol

Synonyms:2-Piperidinone, 3,4-dihydroxy-1-methyl-4-(4-pyridinyl)- (9CI)

Chemical Property of 2-Piperidinone, 3,4-dihydroxy-1-methyl-4-(4-pyridinyl)- (9CI)

Chemical Property:

• PSA: 73.66000
• LogP: -0.56990

Purity/Quality:

99% ^*data from raw suppliers

2-PIPERIDINONE, 3,4-DIHYDROXY-1-METHYL-4-(4-PYRIDINYL)- 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Piperidinone, 3,4-dihydroxy-1-methyl-4-(4-pyridinyl)- (9CI)

There total 3 articles about 2-Piperidinone, 3,4-dihydroxy-1-methyl-4-(4-pyridinyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1-methyl-4-(4'-pyridyl)-1,2,5,6-tetrahydropyridine (140111-43-9) → 3,4-dihydroxy-1-methyl-2-oxo-4-(4-pyridyl)piperidine (446027-96-9)

Guidance literature:

With potassium permanganate; water; In acetonitrile; at 25 ℃;

DOI:10.1007/BF01169230

Reference yield: 45.0%

1-methyl-4-(4-pyridyl)-1,2,5,6-tetrahydropyridin-2-one → 3,4-dihydroxy-1-methyl-2-oxo-4-(4-pyridyl)piperidine (446027-96-9)

Guidance literature:

With potassium permanganate; In water; acetonitrile; at 20 ℃; for 2h;

DOI:10.1023/A:1017570313032

Reference yield:

1-methyl-4-(4-pyridyl)pyridinium iodide (38873-01-7) → 3,4-dihydroxy-1-methyl-2-oxo-4-(4-pyridyl)piperidine (446027-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / NaBH₄ / methanol / 20 deg C, 0.5 h, reflux, 1 h

2: 10 percent / KMnO₄ / H₂O; acetone

With sodium tetrahydroborate; potassium permanganate; In methanol; water; acetone;

DOI:10.1007/BF02503786

upstream raw materials:

1-methyl-4-(4'-pyridyl)-1,2,5,6-tetrahydropyridine

1-methyl-4-(4-pyridyl)pyridinium iodide