N-[7-[2-chloro-4-(1,2,4-oxadiazol-3-yl)phenyl]-6-(4-chlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-2,2-dimethylpropanamide

Base Information

Chemical Name:N-[7-[2-chloro-4-(1,2,4-oxadiazol-3-yl)phenyl]-6-(4-chlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-2,2-dimethylpropanamide
CAS No.:1044586-58-4
Molecular Formula:C₂₉H₂₈Cl₂N₄O₃
Molecular Weight:551.472
Hs Code.:

Synonyms:N-[7-[2-chloro-4-(1,2,4-oxadiazol-3-yl)phenyl]-6-(4-chlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-2,2-dimethylpropanamide

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Chemical Property of N-[7-[2-chloro-4-(1,2,4-oxadiazol-3-yl)phenyl]-6-(4-chlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-2,2-dimethylpropanamide

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Technology Process of N-[7-[2-chloro-4-(1,2,4-oxadiazol-3-yl)phenyl]-6-(4-chlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-2,2-dimethylpropanamide

There total 5 articles about N-[7-[2-chloro-4-(1,2,4-oxadiazol-3-yl)phenyl]-6-(4-chlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1044588-62-6
N-[7-{2-chloro-4-[(hydroxyamino)(imino)methyl]phenyl}-6-(4-chlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-2,2-dimethylpropanamide

: 122-51-0
orthoformic acid triethyl ester

: 1044586-58-4
N-[7-[2-chloro-4-(1,2,4-oxadiazol-3-yl)phenyl]-6-(4-chlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-2,2-dimethylpropanamide

Guidance literature:: With boron trifluoride diethyl etherate; at 110 ℃; for 1h;

Reference yield:

: 1044588-35-3
7-(4-bromo-2-chlorophenyl)-6-(4-chloro-phenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-amine

: 1044586-58-4
N-[7-[2-chloro-4-(1,2,4-oxadiazol-3-yl)phenyl]-6-(4-chlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene / water; N,N-dimethyl-formamide / 16 h / 120 °C

3: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 16 h / Heating / reflux

4: boron trifluoride diethyl etherate / 1 h / 110 °C

With boron trifluoride diethyl etherate; hydroxylamine hydrochloride; sodium hydrogencarbonate; triethylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1044588-27-3
N-[7-(4-bromo-2-chlorophenyl)-6-(4-chlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-2,2-dimethylpropanamide

: 1044586-58-4
N-[7-[2-chloro-4-(1,2,4-oxadiazol-3-yl)phenyl]-6-(4-chlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene / water; N,N-dimethyl-formamide / 16 h / 120 °C

2: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 16 h / Heating / reflux

3: boron trifluoride diethyl etherate / 1 h / 110 °C

With boron trifluoride diethyl etherate; hydroxylamine hydrochloride; sodium hydrogencarbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene; In ethanol; water; N,N-dimethyl-formamide;