(R)-2-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-fluorophenyl)ethanol

Base Information

Chemical Name:(R)-2-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-fluorophenyl)ethanol
CAS No.:1453851-99-4
Molecular Formula:C₁₄H₂₂ClFO₂Si
Molecular Weight:304.864
Hs Code.:

Synonyms:(R)-2-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-fluorophenyl)ethanol

Suppliers and Price of (R)-2-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-fluorophenyl)ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-fluorophenyl)ethanol

Chemical Property:

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Technology Process of (R)-2-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-fluorophenyl)ethanol

There total 3 articles about (R)-2-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-fluorophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312718-88-9
2-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-fluorophenyl)ethanone

: 1453851-99-4
(R)-2-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-fluorophenyl)ethanol

Guidance literature:: With borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tert-butyl methyl ether; toluene; at 40 ℃; for 0.75h;

Reference yield:

: 67226-78-2
ethyl 2-(tert-butyldimethylsilyloxy)acetate

: 1453851-99-4
(R)-2-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-fluorophenyl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl magnesium chloride; N,O-dimethylhydroxylamine*hydrochloride / tetrahydrofuran / 4.5 h / 20 °C / Cooling with ice

2: tetrahydrofuran / 2 h / Cooling with ice

3: borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene; tert-butyl methyl ether / 0.75 h / 40 °C

With borane N,N-diethylaniline complex; N,O-dimethylhydroxylamine*hydrochloride; isopropyl magnesium chloride; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; tert-butyl methyl ether; toluene; 2: |Grignard Reaction;

Reference yield:

: 163089-34-7
N-methoxy-N-methyl-2-(1,1,2,2-tetramethyl-1-silapropoxy)acetamide

: 1453851-99-4
(R)-2-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-fluorophenyl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 2 h / Cooling with ice

2: borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene; tert-butyl methyl ether / 0.75 h / 40 °C

With borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; tert-butyl methyl ether; toluene; 1: |Grignard Reaction;