Technology Process of 3-((1-(3-methoxyphenyl)-1H-indol-6-yl)methyl)benzoic acid
There total 5 articles about 3-((1-(3-methoxyphenyl)-1H-indol-6-yl)methyl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-methoxy-1-iodobenzene; 3-(1H-indol-6-ylmethyl)benzoic acid;
With
potassium hydroxide;
copper(I) oxide;
In
dimethyl sulfoxide;
at 135 ℃;
for 24h;
Inert atmosphere;
With
water; sodium hydroxide;
In
dimethylsulfoxide-d6;
at 20 ℃;
for 3h;
With
hydrogenchloride;
In
water; dimethyl sulfoxide;
pH=3;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / water; tetrahydrofuran / 4 h / 80 °C / Inert atmosphere
2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 °C
2.2: pH 3
3.1: potassium hydroxide / copper(I) oxide / dimethyl sulfoxide / 24 h / 135 °C / Inert atmosphere
3.2: 3 h / 20 °C
3.3: pH 3
With
water; potassium carbonate; potassium hydroxide; sodium hydroxide;
copper(I) oxide; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / water; tetrahydrofuran / 4 h / 80 °C / Inert atmosphere
2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 °C
2.2: pH 3
3.1: potassium hydroxide / copper(I) oxide / dimethyl sulfoxide / 24 h / 135 °C / Inert atmosphere
3.2: 3 h / 20 °C
3.3: pH 3
With
water; potassium carbonate; potassium hydroxide; sodium hydroxide;
copper(I) oxide; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide;
