(Z)-3-((2S,3S)-3-{(4R,5S)-4-[(R)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxan-5-yl}-2-methyl-oxiranyl)-acrylic acid ethyl ester

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Chemical Name:(Z)-3-((2S,3S)-3-{(4R,5S)-4-[(R)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxan-5-yl}-2-methyl-oxiranyl)-acrylic acid ethyl ester
CAS No.:856433-61-9
Molecular Formula:C₂₅H₃₆O₇
Molecular Weight:448.557
Hs Code.:

Synonyms:(Z)-3-((2S,3S)-3-{(4R,5S)-4-[(R)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxan-5-yl}-2-methyl-oxiranyl)-acrylic acid ethyl ester

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Chemical Property of (Z)-3-((2S,3S)-3-{(4R,5S)-4-[(R)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxan-5-yl}-2-methyl-oxiranyl)-acrylic acid ethyl ester

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Technology Process of (Z)-3-((2S,3S)-3-{(4R,5S)-4-[(R)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxan-5-yl}-2-methyl-oxiranyl)-acrylic acid ethyl ester

There total 5 articles about (Z)-3-((2S,3S)-3-{(4R,5S)-4-[(R)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxan-5-yl}-2-methyl-oxiranyl)-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 856433-58-4
(4R,5S)-4-[(R)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxane-5-carbaldehyde

: 856433-61-9
(Z)-3-((2S,3S)-3-{(4R,5S)-4-[(R)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxan-5-yl}-2-methyl-oxiranyl)-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / toluene / 12 h / 70 °C

2.1: 99 percent / DIBAL / tetrahydrofuran; hexane / 0.5 h / 0 °C

3.1: mCPBA / CH₂Cl₂ / 1 h / 0 °C

3.2: pyridine; Dess-Martin periodinane; H₂O / CH₂Cl₂ / 2 h / 20 °C

3.3: 2.44 g / KHMDS / tetrahydrofuran; toluene / 1 h / 0 °C

With diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane; toluene; 1.1: Wittig reaction / 3.2: Dess-Martin oxidation / 3.3: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/ol050569a

Reference yield:

: 856433-57-3
(2S,3R,4R)-5-(4-Methoxy-benzyloxy)-4-methyl-2-vinyl-pentane-1,3-diol

: 856433-61-9
(Z)-3-((2S,3S)-3-{(4R,5S)-4-[(R)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxan-5-yl}-2-methyl-oxiranyl)-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1.20 g / PPTS / CH₂Cl₂ / 1.5 h / 20 °C

2.1: OsO₄; NMO / acetone; H₂O; 2-methyl-propan-2-ol / 12 h / 20 °C

2.2: 91 percent / sodium periodate / acetone; H₂O; 2-methyl-propan-2-ol / 1 h

3.1: 98 percent / toluene / 12 h / 70 °C

4.1: 99 percent / DIBAL / tetrahydrofuran; hexane / 0.5 h / 0 °C

5.1: mCPBA / CH₂Cl₂ / 1 h / 0 °C

5.2: pyridine; Dess-Martin periodinane; H₂O / CH₂Cl₂ / 2 h / 20 °C

5.3: 2.44 g / KHMDS / tetrahydrofuran; toluene / 1 h / 0 °C

With osmium(VIII) oxide; N-methyl-2-indolinone; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane; water; acetone; toluene; tert-butyl alcohol; 3.1: Wittig reaction / 5.2: Dess-Martin oxidation / 5.3: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/ol050569a

Reference yield:

: 856433-70-0
(4R,5S)-4-[(R)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2-dimethyl-5-vinyl-[1,3]dioxane

: 856433-61-9
(Z)-3-((2S,3S)-3-{(4R,5S)-4-[(R)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxan-5-yl}-2-methyl-oxiranyl)-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: OsO₄; NMO / acetone; H₂O; 2-methyl-propan-2-ol / 12 h / 20 °C

1.2: 91 percent / sodium periodate / acetone; H₂O; 2-methyl-propan-2-ol / 1 h

2.1: 98 percent / toluene / 12 h / 70 °C

3.1: 99 percent / DIBAL / tetrahydrofuran; hexane / 0.5 h / 0 °C

4.1: mCPBA / CH₂Cl₂ / 1 h / 0 °C

4.2: pyridine; Dess-Martin periodinane; H₂O / CH₂Cl₂ / 2 h / 20 °C

4.3: 2.44 g / KHMDS / tetrahydrofuran; toluene / 1 h / 0 °C

With osmium(VIII) oxide; N-methyl-2-indolinone; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane; water; acetone; toluene; tert-butyl alcohol; 2.1: Wittig reaction / 4.2: Dess-Martin oxidation / 4.3: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/ol050569a