(1R,2R)-N,N'-bis[(-)-menthoxycarbonyl]-1,2-bis(3,5-dimethoxyphenyl)ethane-1,2-diamine

Base Information

• Chemical Name: (1R,2R)-N,N'-bis[(-)-menthoxycarbonyl]-1,2-bis(3,5-dimethoxyphenyl)ethane-1,2-diamine
• CAS No.: 850255-03-7
• Molecular Formula: C₄₀H₆₀N₂O₈
• Molecular Weight: 696.925
• Mol file: 850255-03-7.mol

Synonyms:(1R,2R)-N,N'-bis[(-)-menthoxycarbonyl]-1,2-bis(3,5-dimethoxyphenyl)ethane-1,2-diamine

Chemical Property of (1R,2R)-N,N'-bis[(-)-menthoxycarbonyl]-1,2-bis(3,5-dimethoxyphenyl)ethane-1,2-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-N,N'-bis[(-)-menthoxycarbonyl]-1,2-bis(3,5-dimethoxyphenyl)ethane-1,2-diamine

There total 1 articles about (1R,2R)-N,N'-bis[(-)-menthoxycarbonyl]-1,2-bis(3,5-dimethoxyphenyl)ethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

(1R,2S,5R)-menthyl chloroformate (14602-86-9,7635-53-2) + (+/-)-1,2-bis(3,5-dimethoxyphenyl)ethane-1,2-diamine → (1R,2R)-N,N'-bis[(-)-menthoxycarbonyl]-1,2-bis(3,5-dimethoxyphenyl)ethane-1,2-diamine (850255-03-7) + (1S,2S)-N,N'-bis[(-)-menthoxycarbonyl]-1,2-bis(3,5-dimethoxyphenyl)ethane-1,2-diamine

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1055/s-2004-834953

Reference yield:

(1R,2R)-N,N'-bis[(-)-menthoxycarbonyl]-1,2-bis(3,5-dimethoxyphenyl)ethane-1,2-diamine (850255-03-7) → 1,2-bis-(3,5-dimethoxy-phenyl)-N,N'-dimethyl-ethane-1,2-diamine

Guidance literature:

With lithium aluminium tetrahydride; In 1,2-dimethoxyethane; at 85 ℃; for 20h;

DOI:10.1055/s-2004-834953

Reference yield:

(1R,2R)-N,N'-bis[(-)-menthoxycarbonyl]-1,2-bis(3,5-dimethoxyphenyl)ethane-1,2-diamine (850255-03-7) → (4R,5R)-4,5-bis(3,5-dimethoxyphenyl)-1,2,3-trimethylimidazolidine (850255-04-8)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / 1,2-dimethoxy-ethane / 20 h / 85 °C

2: 300 mg / 4 Angstroem molecular sieves / diethyl ether / 1 h / 20 °C

With lithium aluminium tetrahydride; 4 A molecular sieve; In 1,2-dimethoxyethane; diethyl ether;

DOI:10.1055/s-2004-834953

upstream raw materials:

(1R,2S,5R)-menthyl chloroformate

Downstream raw materials:

(4R,5R)-4,5-bis(3,5-dimethoxyphenyl)-1,2,3-trimethylimidazolidine

5,5'-[(4R,5R)-1,2,3-trimethylimidazolidine-4,5-diyl]dibenzene-1,2-diol