Technology Process of 5-((Z)-Hex-3-ene-1,5-diynyl)-3,6,6-trimethoxy-5-triethylsilanyloxy-cyclohexa-1,3-dienecarboxylic acid ethyl ester
There total 6 articles about 5-((Z)-Hex-3-ene-1,5-diynyl)-3,6,6-trimethoxy-5-triethylsilanyloxy-cyclohexa-1,3-dienecarboxylic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,6-dimethylpyridine; potassium carbonate;
In
dichloromethane;
at -78 ℃;
for 2h;
Yield given;
DOI:10.1021/ja982125y
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / SOCl2
2: 87 percent / iodobenzene diacetate / 0.5 h / 0 °C
3: 1.) hexamethyldisilazane, n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, a) -78 deg C, 30 min, b) -45 deg C, 1.5 h
4: 23.0 g / tetra-n-butylammonium fluoride / tetrahydrofuran / 16 h / -78 °C
5: K2CO3, 2,6-lutidine / CH2Cl2 / 2 h / -78 °C
With
2,6-dimethylpyridine; n-butyllithium; thionyl chloride; [bis(acetoxy)iodo]benzene; tetrabutyl ammonium fluoride; potassium carbonate; 1,1,1,3,3,3-hexamethyl-disilazane;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja982125y
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 87 percent / iodobenzene diacetate / 0.5 h / 0 °C
2: 1.) hexamethyldisilazane, n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, a) -78 deg C, 30 min, b) -45 deg C, 1.5 h
3: 23.0 g / tetra-n-butylammonium fluoride / tetrahydrofuran / 16 h / -78 °C
4: K2CO3, 2,6-lutidine / CH2Cl2 / 2 h / -78 °C
With
2,6-dimethylpyridine; n-butyllithium; [bis(acetoxy)iodo]benzene; tetrabutyl ammonium fluoride; potassium carbonate; 1,1,1,3,3,3-hexamethyl-disilazane;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja982125y
