N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-3,4-dihydro-[1,6]naphthyridin-7-yl]-N-(3-hydroxy-propyl)-acetamide

Base Information

Chemical Name:N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-3,4-dihydro-[1,6]naphthyridin-7-yl]-N-(3-hydroxy-propyl)-acetamide
CAS No.:862370-22-7
Molecular Formula:C₂₆H₃₅N₅O₅
Molecular Weight:497.594
Hs Code.:

<i>N</i>-[2-(3-<i>tert</i>-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-3,4-dihydro-[1,6]naphthyridin-7-yl]-<i>N</i>-(3-hydroxy-propyl)-acetamide

Synonyms:N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-3,4-dihydro-[1,6]naphthyridin-7-yl]-N-(3-hydroxy-propyl)-acetamide

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Chemical Property of N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-3,4-dihydro-[1,6]naphthyridin-7-yl]-N-(3-hydroxy-propyl)-acetamide

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Technology Process of N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-3,4-dihydro-[1,6]naphthyridin-7-yl]-N-(3-hydroxy-propyl)-acetamide

There total 1 articles about N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-3,4-dihydro-[1,6]naphthyridin-7-yl]-N-(3-hydroxy-propyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 862370-09-0
N-(3-benzyloxy-propyl)-N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-7-yl]-acetamide

: N-[3-(benzyloxy)propyl]-N-[3-(3,5-dimethoxyphenyl)-1,2,3,4-tetrahydro-1,6-naphthyridin-7-yl]acetamide

: 862370-15-8
N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-7-yl]-N-(3-hydroxy-propyl)-acetamide

: 862370-22-7
N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-3,4-dihydro-[1,6]naphthyridin-7-yl]-N-(3-hydroxy-propyl)-acetamide

: N-(3-benzyloxy-propyl)-N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-3,4-dihydro-[1,6]naphthyridin-7-yl]-acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 48h; under 3102.89 Torr; Further byproducts given. Title compound not separated from byproducts;
DOI:10.1021/jm0500931

Reference yield: 98.0%

: 862370-22-7
N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-3,4-dihydro-[1,6]naphthyridin-7-yl]-N-(3-hydroxy-propyl)-acetamide

: 862370-15-8
N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-7-yl]-N-(3-hydroxy-propyl)-acetamide

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm0500931

Reference yield:

: 862370-22-7
N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-3,4-dihydro-[1,6]naphthyridin-7-yl]-N-(3-hydroxy-propyl)-acetamide

: N-[3-(benzyloxy)propyl]-N-[3-(3,5-dimethoxyphenyl)-1,2,3,4-tetrahydro-1,6-naphthyridin-7-yl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / DDQ / CH₂Cl₂ / 3 h / 20 °C

2: 9 mg / pyridine / 14 h / 20 °C

With pyridine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane;
DOI:10.1021/jm0500931