Lys-boc octreotide 3-tritylmercaptopropionamide

Base Information

• Chemical Name: Lys-boc octreotide 3-tritylmercaptopropionamide
• CAS No.: 1616776-08-9
• Molecular Formula: C₇₆H₉₂N₁₀O₁₃S₃
• Molecular Weight: 1449.82
• Mol file: 1616776-08-9.mol

Synonyms:Lys-boc octreotide 3-tritylmercaptopropionamide

Chemical Property of Lys-boc octreotide 3-tritylmercaptopropionamide

Chemical Property:

Purity/Quality:

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Technology Process of Lys-boc octreotide 3-tritylmercaptopropionamide

There total 2 articles about Lys-boc octreotide 3-tritylmercaptopropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Lys-Boc octereotide acetate + 3-(triphenylmethylthio)propionic acid N-hydroxysuccinimide ester (129431-12-5) → Lys-boc octreotide 3-tritylmercaptopropionamide (1616776-08-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 50 ℃; for 2h;

Reference yield: 77.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-(triphenylmethylthio)propionic acid N-hydroxysuccinimide ester (129431-12-5) + octreotide acetate (79517-01-4) → Lys-boc octreotide 3-tritylmercaptopropionamide (1616776-08-9)

Guidance literature:

di-tert-butyl dicarbonate; octreotide acetate; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

3-(triphenylmethylthio)propionic acid N-hydroxysuccinimide ester; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 69.0%

C57H73N3O15S2 (1616835-66-5) + Lys-boc octreotide 3-tritylmercaptopropionamide (1616776-08-9) → C104H138N12O26S4

Guidance literature:

Lys-boc octreotide 3-tritylmercaptopropionamide; With chlorotriisopropylsilane; trifluoroacetic acid; at 20 ℃; for 0.0833333h;

C₅₇H₇₃N₃O₁₅S₂; In tetrahydrofuran; aq. phosphate buffer; at 20 ℃; for 2h; pH=8;

upstream raw materials:

di-tert-butyl dicarbonate

3-(triphenylmethylthio)propionic acid N-hydroxysuccinimide ester

octreotide acetate

Downstream raw materials:

C₉₈H₁₁₉N₁₄O₁₄S₃⁽¹⁺⁾*C₂HF₃O₂*C₂F₃O₂^(1-)