4-[2-(2-acetoxyethoxy)methyl-1,2,3,4-tetrahydroquinazolin-2,4-dion-3-yl]benzenesulfonamide

Base Information

Chemical Name:4-[2-(2-acetoxyethoxy)methyl-1,2,3,4-tetrahydroquinazolin-2,4-dion-3-yl]benzenesulfonamide
CAS No.:755002-75-6
Molecular Formula:C₁₉H₁₉N₃O₇S
Molecular Weight:433.442
Hs Code.:

Synonyms:4-[2-(2-acetoxyethoxy)methyl-1,2,3,4-tetrahydroquinazolin-2,4-dion-3-yl]benzenesulfonamide

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Chemical Property of 4-[2-(2-acetoxyethoxy)methyl-1,2,3,4-tetrahydroquinazolin-2,4-dion-3-yl]benzenesulfonamide

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Technology Process of 4-[2-(2-acetoxyethoxy)methyl-1,2,3,4-tetrahydroquinazolin-2,4-dion-3-yl]benzenesulfonamide

There total 2 articles about 4-[2-(2-acetoxyethoxy)methyl-1,2,3,4-tetrahydroquinazolin-2,4-dion-3-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 81777-40-4
2-acetoxyethoxymethyl bromide

: 4392-51-2
4-[1,2,3,4-tetrahydroquinazolin-2,4-dion-3-yl]benzenesulfonamide

: 755002-75-6
4-[2-(2-acetoxyethoxy)methyl-1,2,3,4-tetrahydroquinazolin-2,4-dion-3-yl]benzenesulfonamide

Guidance literature:: 4-[1,2,3,4-tetrahydroquinazolin-2,4-dion-3-yl]benzenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

2-acetoxyethoxymethyl bromide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1080/10426500490459678

Reference yield:

: 170806-07-2
dimethyl N-<4-(4-oxo-2-thioxo-1,2,3,4-tetrahydro-3-quinazolinylphenylsulphonyl)>dithiocarbonoimidate

: 755002-75-6
4-[2-(2-acetoxyethoxy)methyl-1,2,3,4-tetrahydroquinazolin-2,4-dion-3-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 82 percent / aq. ClCH₂COOH / 24 h / 20 °C

2.1: sodium hydride / dimethylformamide / 1 h / 20 °C

2.2: 62 percent / dimethylformamide / 20 °C

With sodium hydride; chloroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1080/10426500490459678