4-(3,5-diphenyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)pyrimidine

Base Information

• Chemical Name: 4-(3,5-diphenyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)pyrimidine
• CAS No.: 357614-52-9
• Molecular Formula: C₂₄H₂₃N₅
• Molecular Weight: 381.48
• Mol file: 357614-52-9.mol

Synonyms:4-(3,5-diphenyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)pyrimidine

Chemical Property of 4-(3,5-diphenyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3,5-diphenyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)pyrimidine

There total 2 articles about 4-(3,5-diphenyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1,3-diphenylpropanedione (120-46-7,61346-73-4) + 4-hydrazino-6-(piperidin-1-yl)pyrimidine (10019-46-2) → 4-(3,5-diphenyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)pyrimidine (357614-52-9)

Guidance literature:

In ethanol; for 8h; Reflux;

DOI:10.1016/j.ica.2010.01.013

Reference yield: 62.0%

piperidine (110-89-4) + 4-chloro-6-(3,5-diphenyl-1H-pyrazol-1-yl)pyrimidine (357614-46-1) → 4-(3,5-diphenyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)pyrimidine (357614-52-9)

Guidance literature:

In ethanol; for 1h; Reflux;

DOI:10.1016/j.ica.2010.01.013

Reference yield: 98.0%

aqueous cadmium chloride + 4-(3,5-diphenyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)pyrimidine (357614-52-9) → [CdCl2(4-(3,5-diphenyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)pyrimidine)2] (1310572-93-0)

Guidance literature:

In ethanol; acetone; hot EtOH soln. of ZnCl2 added to hot EtOH/Me2CO (5/1, v/v) soln. of ligand (1:3 molar ratio), mixt. stirred for 1 h; ppt. filtered off, washed (EtOH), dried in air, elem. anal.;

DOI:10.1016/j.ica.2011.03.007

upstream raw materials:

piperidine

4-chloro-6-(3,5-diphenyl-1H-pyrazol-1-yl)pyrimidine

1,3-diphenylpropanedione

4-hydrazino-6-(piperidin-1-yl)pyrimidine

Downstream raw materials:

trans-[CuCl₂(4-(3,5-diphenyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)pyrimidine)2]

[CdCl₂(4-(3,5-diphenyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)pyrimidine)]

[CdCl₂(4-(3,5-diphenyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)pyrimidine)2]

[ZnCl₂(4-(3,5-diphenyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)pyrimidine)]