cyclohexyl-methyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester

Base Information

• Chemical Name: cyclohexyl-methyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester
• CAS No.: 209394-74-1
• Molecular Formula: C₂₂H₃₂N₂O₄
• Molecular Weight: 388.507

Synonyms:cyclohexyl-methyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester

Chemical Property of cyclohexyl-methyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester

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Technology Process of cyclohexyl-methyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester

There total 2 articles about cyclohexyl-methyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methyl-N-cyclohexylaminocarbonyl chloride (35028-38-7) + 6-hydroxy-N-Boc 1-aminoindan (209394-60-5) → cyclohexyl-methyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester (209394-74-1)

Guidance literature:

With sodium hydride; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1021/jm020120c

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → cyclohexyl-methyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester (209394-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / Et₃N / tetrahydrofuran / 20 h / 20 °C

2: NaH / acetonitrile / 2 h / 20 °C

With sodium hydride; triethylamine; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm020120c

Reference yield:

cyclohexyl-methyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester (209394-74-1) → cyclohexyl-methyl-carbamic acid 3-amino-indan-5-yl ester; hydrochloride

Guidance literature:

With 20percent HCl; In 1,4-dioxane; at 20 ℃; for 2h;

DOI:10.1021/jm020120c

upstream raw materials:

N-methyl-N-cyclohexylaminocarbonyl chloride

6-hydroxy-N-Boc 1-aminoindan

di-tert-butyl dicarbonate

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