(R,R)-2-methyl-propane-2-sulfinic acid [1-(4-fluoro-phenyl)-2-nitro-ethyl]-amide

Base Information

• Chemical Name: (R,R)-2-methyl-propane-2-sulfinic acid [1-(4-fluoro-phenyl)-2-nitro-ethyl]-amide
• CAS No.: 1267688-19-6
• Molecular Formula: C₁₂H₁₇FN₂O₃S
• Molecular Weight: 288.343

Synonyms:(R,R)-2-methyl-propane-2-sulfinic acid [1-(4-fluoro-phenyl)-2-nitro-ethyl]-amide

Chemical Property of (R,R)-2-methyl-propane-2-sulfinic acid [1-(4-fluoro-phenyl)-2-nitro-ethyl]-amide

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Technology Process of (R,R)-2-methyl-propane-2-sulfinic acid [1-(4-fluoro-phenyl)-2-nitro-ethyl]-amide

There total 2 articles about (R,R)-2-methyl-propane-2-sulfinic acid [1-(4-fluoro-phenyl)-2-nitro-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

nitromethane (75-52-5) + (R)-N-(4-fluorobenzylidene)-2-methylpropane-2-sulfinamide (1267688-18-5) → (R,R)-2-methyl-propane-2-sulfinic acid [1-(4-fluoro-phenyl)-2-nitro-ethyl]-amide (1267688-19-6)

Guidance literature:

nitromethane; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

(R)-N-(4-fluorobenzylidene)-2-methylpropane-2-sulfinamide; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere;

With acetic acid; In tetrahydrofuran; at 20 ℃; pH=5; Inert atmosphere;

Reference yield:

4-fluorobenzaldehyde (459-57-4) → (R,R)-2-methyl-propane-2-sulfinic acid [1-(4-fluoro-phenyl)-2-nitro-ethyl]-amide (1267688-19-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0 °C / Inert atmosphere

2.2: 16 h / 0 - 20 °C / Inert atmosphere

2.3: 20 °C / pH 5 / Inert atmosphere

With potassium tert-butylate; titanium(IV) tetraethanolate; In tetrahydrofuran;

Reference yield: 89.0%

(R,R)-2-methyl-propane-2-sulfinic acid [1-(4-fluoro-phenyl)-2-nitro-ethyl]-amide (1267688-19-6) → (R,R)-2-methyl-propane-2-sulfinic acid [2-amino-1-(4-fluoro-phenyl)-ethyl]-amide (1267688-21-0)

Guidance literature:

With water; ammonium chloride; zinc; In acetone; at 20 ℃; for 0.166667h; Inert atmosphere;

upstream raw materials:

nitromethane

(R)-N-(4-fluorobenzylidene)-2-methylpropane-2-sulfinamide

4-fluorobenzaldehyde

Downstream raw materials:

(1R)-N₂-[6-(3-chloro-4-trifluoromethyl-phenyl)-pyrimidin-4-yl]-1-(4-fluoro-phenyl)-ethane-1,2-diamine

(R,R)-2-methyl-propane-2-sulfinic acid [2-amino-1-(4-fluoro-phenyl)-ethyl]-amide

(R,R)-2-methyl-propane-2-sulfinic acid [2-[6-(3-chloro-4-trifluoromethyl-phenyl)pyrimidin-4-ylamino]-1-(4-fluoro-phenyl)-ethyl]-amide

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