N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-isopropoxyacetamide hydrochloride

Base Information

Chemical Name:N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-isopropoxyacetamide hydrochloride
CAS No.:1372180-06-7
Molecular Formula:C₁₇H₂₄ClFN₂O₃*ClH
Molecular Weight:395.302
Hs Code.:

Synonyms:N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-isopropoxyacetamide hydrochloride

Suppliers and Price of N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-isopropoxyacetamide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-isopropoxyacetamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-isopropoxyacetamide hydrochloride

There total 19 articles about N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-isopropoxyacetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1372187-12-6
(6R,7R)-tert-butyl 7-(4-chloro-3-fluorophenyl)-6-((2-isopropoxyacetamido)methyl)-1,4-oxazepane-4-carboxylate

: 1372180-06-7
N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-isopropoxyacetamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2016.05.038

Reference yield:

: 1372187-08-0
(6S,7R)-tert-butyl 6-(azidomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate

: 1372180-06-7
N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-isopropoxyacetamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 10 - 35 °C

3: hydrogenchloride / ethyl acetate / 1 h / 10 - 35 °C

With hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; ethyl acetate; 1: Staudinger Reaction;

Reference yield:

: 1372187-07-9
(6S,7R)-tert-butyl 7-(4-chloro-3-fluorophenyl)-6-((methylsulfonyloxy)methyl)-1,4-oxazepane-4-carboxylate

: 1372180-06-7
N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-isopropoxyacetamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 70 °C

2: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 10 - 35 °C

4: hydrogenchloride / ethyl acetate / 1 h / 10 - 35 °C

With hydrogenchloride; sodium azide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; 2: Staudinger Reaction;