1-tert-butyl 6-ethyl 2-benzyl-3-isopropyl-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 6-ethyl 2-benzyl-3-isopropyl-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate
CAS No.:1434004-08-6
Molecular Formula:C₂₇H₃₃N₃O₄
Molecular Weight:463.577
Hs Code.:

Synonyms:1-tert-butyl 6-ethyl 2-benzyl-3-isopropyl-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate

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Chemical Property of 1-tert-butyl 6-ethyl 2-benzyl-3-isopropyl-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate

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Technology Process of 1-tert-butyl 6-ethyl 2-benzyl-3-isopropyl-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate

There total 3 articles about 1-tert-butyl 6-ethyl 2-benzyl-3-isopropyl-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1434003-97-0
tert-butyl 5-[2-azido-4-(ethoxycarbonyl)phenyl]-2-benzyl-3-isopropyl-2,3-dihydro-1H-pyrazole-1-carboxylate

: 1434004-08-6
1-tert-butyl 6-ethyl 2-benzyl-3-isopropyl-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate

Guidance literature:: With rhodium(III) chloride hydrate; In 1,2-dimethoxyethane; at 80 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c3ob40223a

Reference yield:

: 1434003-91-4
ethyl 3-azido-4-ethynylbenzoate

: 1434004-08-6
1-tert-butyl 6-ethyl 2-benzyl-3-isopropyl-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: silver trifluoromethanesulfonate; [AuCl(IPr)] / 1,2-dichloro-ethane / 50 °C / Inert atmosphere

2: rhodium(III) chloride hydrate / 1,2-dimethoxyethane / 4 h / 80 °C / Inert atmosphere

With rhodium(III) chloride hydrate; [AuCl(IPr)]; silver trifluoromethanesulfonate; In 1,2-dimethoxyethane; 1,2-dichloro-ethane;
DOI:10.1039/c3ob40223a

Reference yield:

: 1260650-82-5
C₁₁H₁₁NO₂

: 1434004-08-6
1-tert-butyl 6-ethyl 2-benzyl-3-isopropyl-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium nitrite; sulfuric acid / water; acetonitrile; N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 0.5 h / 0 - 20 °C

2.1: silver trifluoromethanesulfonate; [AuCl(IPr)] / 1,2-dichloro-ethane / 50 °C / Inert atmosphere

3.1: rhodium(III) chloride hydrate / 1,2-dimethoxyethane / 4 h / 80 °C / Inert atmosphere

With rhodium(III) chloride hydrate; sulfuric acid; [AuCl(IPr)]; silver trifluoromethanesulfonate; sodium nitrite; In 1,2-dimethoxyethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ob40223a