Technology Process of 3-Furanpropanoicacid,3-ethyltetrahydro-2-methoxy-,(3R)-(9CI)
There total 9 articles about 3-Furanpropanoicacid,3-ethyltetrahydro-2-methoxy-,(3R)-(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-((R)-3-Ethyl-2-methoxy-tetrahydro-furan-3-yl)-propan-1-ol;
With
pyridine-SO3 complex; TEA; dimethyl sulfoxide;
In
dichloromethane;
at 20 ℃;
for 0.5h;
With
2-methyl-but-2-ene; tert-butyl alcohol;
In
phosphate buffer;
at 20 ℃;
for 1h;
DOI:10.1016/S0040-4039(02)00256-3
- Guidance literature:
-
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene;
In
water; tert-butyl alcohol;
at 20 ℃;
for 1h;
DOI:10.1016/j.tet.2004.02.015
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: diisobutylaluminum hydride / diethyl ether / 1 h / -78 °C
1.2: 84 percent / p-toluenesulfonic acid / methanol / 0.67 h / Heating
2.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran; hexane / 20 °C
2.2: 87 percent / aq. NaOH; H2O2 / tetrahydrofuran; hexane / 0 - 20 °C
3.1: sulfur trioxide pyridine complex; methyl sulfoxide; triethylamine / CH2Cl2 / 0.5 h / 20 °C
4.1: 95 percent / 2-methyl-2-butene; sodium dihydrogenphosphate dihydrate; sodium chlorite / 2-methyl-propan-2-ol; H2O / 1 h / 20 °C
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sulfur trioxide pyridine complex; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; 9-bora-bicyclo[3.3.1]nonane;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.tet.2004.02.015
