(1S,2R)-2-((R)-1-Amino-ethyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

Base Information

Chemical Name:(1S,2R)-2-((R)-1-Amino-ethyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide
CAS No.:172015-89-3
Molecular Formula:C₁₆H₂₄N₂O
Molecular Weight:260.379
Hs Code.:

Synonyms:(1S,2R)-2-((R)-1-Amino-ethyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

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Chemical Property of (1S,2R)-2-((R)-1-Amino-ethyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

Chemical Property:

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Technology Process of (1S,2R)-2-((R)-1-Amino-ethyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

There total 9 articles about (1S,2R)-2-((R)-1-Amino-ethyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 172015-99-5
(1 S,2 R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropane-carboxamide

: 172015-89-3
(1S,2R)-2-((R)-1-Amino-ethyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1) CH₂Cl₂, -78 deg C, 2 h; 2) CH₂Cl₂, -78 deg C, 1 h

2: 93 percent / tetrahydrofuran / 2 h / -20 °C

3: 94 percent / PDC, molecular sieves 4 Angstroem / CH₂Cl₂ / 2 h / Ambient temperature

4: 90 percent / DIBAL-H / tetrahydrofuran; hexane / 1 h / -78 °C

5: 86 percent / NaN₃, Ph₃P, CBr₄ / dimethylformamide / 3 h / Ambient temperature

6: H₂ / Pd/C / methanol / 1.5 h / Ambient temperature

With dipyridinium dichromate; sodium azide; oxalyl dichloride; carbon tetrabromide; 4 A molecular sieve; hydrogen; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo9518056

Reference yield:

: 172016-00-1
(1S,2R)-2-Formyl-1-phenyl-cyclopropanecarboxylic acid diethylamide

: 172015-89-3
(1S,2R)-2-((R)-1-Amino-ethyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / tetrahydrofuran / 2 h / -20 °C

2: 94 percent / PDC, molecular sieves 4 Angstroem / CH₂Cl₂ / 2 h / Ambient temperature

3: 90 percent / DIBAL-H / tetrahydrofuran; hexane / 1 h / -78 °C

4: 86 percent / NaN₃, Ph₃P, CBr₄ / dimethylformamide / 3 h / Ambient temperature

5: H₂ / Pd/C / methanol / 1.5 h / Ambient temperature

With dipyridinium dichromate; sodium azide; carbon tetrabromide; 4 A molecular sieve; hydrogen; diisobutylaluminium hydride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo9518056

Reference yield:

: 172016-01-2
(1S,2R)-1-phenyl-2-<(R)-1-hydroxyethyl>-N,N-diethylcyclopropanecarboxamide

: 172015-89-3
(1S,2R)-2-((R)-1-Amino-ethyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

Guidance literature:: With sodium azide; carbon tetrabromide; hydrogen; triphenylphosphine; palladium on activated charcoal; Multistep reaction; 1.) DMF, 2.) MeOH;
DOI:10.1016/0040-4039(95)02221-X