1-<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetyl>-4-methylpiperazine

Base Information

Chemical Name:1-<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetyl>-4-methylpiperazine
CAS No.:142843-31-0
Molecular Formula:C₃₇H₅₇N₇O₆S
Molecular Weight:727.969
Hs Code.:

Synonyms:1-<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetyl>-4-methylpiperazine

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Chemical Property of 1-<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetyl>-4-methylpiperazine

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Technology Process of 1-<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetyl>-4-methylpiperazine

There total 6 articles about 1-<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetyl>-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 142866-95-3
4-((S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-{(1S,2R)-1-cyclohexylmethyl-2-hydroxy-3-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethylsulfanyl]-propylcarbamoyl}-ethyl)-imidazole-1-carboxylic acid tert-butyl ester

: 142843-31-0
1-<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetyl>-4-methylpiperazine

Guidance literature:: With ammonia; In methanol; for 3h; Ambient temperature;
DOI:10.1021/jm00093a009

Reference yield:

: 109-01-3
1-methyl-piperazine

: 142843-31-0
1-<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetyl>-4-methylpiperazine

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / ethanol / 3 h / 80 °C

2: ethanolic HCl / 1 h / Ambient temperature

3: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), triethylamine / CH₂Cl₂ / 17 h / Ambient temperature

4: 68 percent / NH₃ (gas) / methanol / 3 h / Ambient temperature

With hydrogenchloride; ammonia; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm00093a009

Reference yield:

: 107202-61-9
(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane

: 142843-31-0
1-<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetyl>-4-methylpiperazine

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / triethylamine / ethanol

2: 100 percent / ethanol / 3 h / 80 °C

3: ethanolic HCl / 1 h / Ambient temperature

4: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), triethylamine / CH₂Cl₂ / 17 h / Ambient temperature

5: 68 percent / NH₃ (gas) / methanol / 3 h / Ambient temperature

With hydrogenchloride; ammonia; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm00093a009